What compounds affect the Stabilization of p53 pathway?

180 compounds in the BiohacksAI corpus have documented interactions with genes in the Stabilization of p53 pathway (Reactome ID: R-HSA-69541). These compounds target 37 genes within this pathway.

What genes are in the Stabilization of p53 pathway?

The Stabilization of p53 pathway involves 37 genes. Key genes include: ADRM1, ATM, CHEK2, MDM2, MDM4, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5.

Stabilization of p53

REACTOME PATHWAY

Reactome: R-HSA-6954137 genes180 compounds

The Stabilization of p53 pathway (Reactome ID: R-HSA-69541) involves 37 genes and is affected by 180 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ATM CHEK2 MDM2 MDM4 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14+7 more

Compounds Affecting Stabilization of p53

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Methylene Blue	—	200
4	sp600125	—	117
5	Hexachlorophene	—	300
6	Azacitidine	—	298
7	Azacitidine	—	300
8	Cladribine	—	297
9	Cytarabine	—	297
10	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
11	Melphalan	—	300
12	Niclosamide	—	299
13	Methotrexate	—	289
14	Trifluridine	—	295
15	Ciclopirox	—	88
16	cycloheximide	—	300
17	Dinitrochlorobenzene	—	300
18	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
19	Vorinostat	—	299
20	Spironolactone	—	298
21	Thioridazine	—	35
22	vinblastine sulfate	—	81
23	Digoxin	—	299
24	Nisoldipine	—	297
25	Nocodazole Nocodazole is	—	215
26	Oxyphenbutazone	—	300
27	rafoxanide	—	172
28	Sertraline	—	1,000
29	Astemizole Antihistamine drug now withdrawn from	—	280
30	Chlorhexidine	—	299
31	Colchicine	—	300
32	Demecolcine	—	246
33	tyrphostin 9	—	2
34	streptonigrin	—	299
35	Lovastatin	—	300
36	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
37	Disulfiram	—	297
38	Quercetin	—	300
39	Genistein	—	300
40	chrysin	—	300
41	Harmaline	—	300
42	Nitrofurantoin	—	297
43	Calcimycin	—	216
44	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
45	Tubercidin	—	300
46	Anisomycin	—	247
47	colchine	—	2
48	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
49	Fluspirilene	—	74
50	gedunin	—	54

About the Stabilization of p53 Pathway

The Stabilization of p53 pathway is catalogued in Reactome (ID: R-HSA-69541) and involves 37 genes. In the BiohacksAI corpus, 180 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ATM, CHEK2, MDM2, MDM4.