What compounds affect the Histidine catabolism pathway?

37 compounds in the BiohacksAI corpus have documented interactions with genes in the Histidine catabolism pathway (Reactome ID: R-HSA-70921). These compounds target 1 genes within this pathway.

What genes are in the Histidine catabolism pathway?

The Histidine catabolism pathway involves 1 genes. Key genes include: HNMT.

Histidine catabolism

REACTOME PATHWAY

Reactome: R-HSA-709211 genes37 compounds

The Histidine catabolism pathway (Reactome ID: R-HSA-70921) involves 1 genes and is affected by 37 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HNMT

Compounds Affecting Histidine catabolism

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Calcimycin	—	216
3	Dequalinium	—	136
4	Ticagrelor	—	299
5	tyrphostin ag 1478	—	4
6	Aurintricarboxylic Acid	—	184
7	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
8	Chlorhexidine	—	299
9	Cisplatin	—	300
10	darapladib [Supplementary Concept]	—	44
11	Dasatinib	—	299
12	Demeclocycline	—	297
13	Iodoacetamide	—	300
14	pictilisib	—	25
15	Vemurafenib	—	298
16	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
17	Thyroxine	—	994
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	Quercetin	—	300
20	2-Methoxyestradiol	—	300
21	Afatinib	—	297
22	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
23	Disulfiram	—	297
24	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
25	Estrone	—	300
26	Guanabenz	—	298
27	Methyldopa	—	297
28	Methylergonovine	—	193
29	Methysergide	—	300
30	piceatannol	—	300
31	propionylpromazine hydrochloride	—	2
32	scriptaid	—	53
33	Suramin	—	300
34	Thiorphan	—	300
35	Thyroxine	—	300
36	Triiodothyronine	—	300
37	tyrphostin 9	—	2

About the Histidine catabolism Pathway

The Histidine catabolism pathway is catalogued in Reactome (ID: R-HSA-70921) and involves 1 genes. In the BiohacksAI corpus, 37 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HNMT.