What compounds affect the Creatine metabolism pathway?

40 compounds in the BiohacksAI corpus have documented interactions with genes in the Creatine metabolism pathway (Reactome ID: R-HSA-71288). These compounds target 4 genes within this pathway.

What genes are in the Creatine metabolism pathway?

The Creatine metabolism pathway involves 4 genes. Key genes include: GAMT, SLC6A11, SLC6A12, SLC6A8.

Creatine metabolism

REACTOME PATHWAY

Reactome: R-HSA-712884 genes40 compounds

The Creatine metabolism pathway (Reactome ID: R-HSA-71288) involves 4 genes and is affected by 40 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GAMT SLC6A11 SLC6A12 SLC6A8

Compounds Affecting Creatine metabolism

#	Compound	Targets Hit	Studies
1	gamma-Aminobutyric Acid	—	300
2	Crizotinib	—	298
3	Calcimycin	—	216
4	Dequalinium	—	136
5	Ticagrelor	—	299
6	tyrphostin ag 1478	—	4
7	Aurintricarboxylic Acid	—	184
8	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
9	Chlorhexidine	—	299
10	Cisplatin	—	300
11	darapladib [Supplementary Concept]	—	44
12	Dasatinib	—	299
13	Demeclocycline	—	297
14	Iodoacetamide	—	300
15	pictilisib	—	25
16	Vemurafenib	—	298
17	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
18	Thyroxine	—	994
19	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
20	Quercetin	—	300
21	2-Methoxyestradiol	—	300
22	Afatinib	—	297
23	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
24	Disulfiram	—	297
25	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
26	Estrone	—	300
27	Guanabenz	—	298
28	Methyldopa	—	297
29	Methylergonovine	—	193
30	Methysergide	—	300
31	piceatannol	—	300
32	propionylpromazine hydrochloride	—	2
33	scriptaid	—	53
34	Suramin	—	300
35	Thiorphan	—	300
36	Thyroxine	—	300
37	Triiodothyronine	—	300
38	tyrphostin 9	—	2
39	Tiagabine	—	298
40	Creatine	—	298

About the Creatine metabolism Pathway

The Creatine metabolism pathway is catalogued in Reactome (ID: R-HSA-71288) and involves 4 genes. In the BiohacksAI corpus, 40 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GAMT, SLC6A11, SLC6A12, SLC6A8.