What genes are in the Regulation of RUNX2 expression and activity pathway?

The Regulation of RUNX2 expression and activity pathway involves 40 genes. Key genes include: ADRM1, CBFB, CUL1, ESR1, ESRRA, GSK3B, NR3C1, PSMA1, PSMA2, PSMA3.

Regulation of RUNX2 expression and activity

Q: What compounds affect the Regulation of RUNX2 expression and activity pathway?

396 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of RUNX2 expression and activity pathway (Reactome ID: R-HSA-8939902). These compounds target 40 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-893990240 genes396 compounds

The Regulation of RUNX2 expression and activity pathway (Reactome ID: R-HSA-8939902) involves 40 genes and is affected by 396 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CBFB CUL1 ESR1 ESRRA GSK3B NR3C1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12+10 more

Compounds Affecting Regulation of RUNX2 expression and activity

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
5	Quercetin	—	300
6	chrysin	—	300
7	Genistein	—	300
8	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
9	Kaempferols	—	300
10	Daunorubicin	—	298
11	Disulfiram	—	297
12	Budesonide	—	1,000
13	Levonorgestrel	—	292
14	Norgestrel	—	300
15	Ethinyl Estradiol	—	300
16	Methyltestosterone	—	300
17	Dehydroepiandrosterone	—	300
18	Dehydroepiandrosterone	—	300
19	Fulvestrant	—	295
20	Dactinomycin	—	297
21	Danazol	—	298
22	Estrone	—	300
23	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
24	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
25	Dihydrotestosterone	—	300
26	Ethidium	—	300
27	Ethynodiol Diacetate	—	300
28	Norethindrone	—	300
29	Testosterone Propionate	—	300
30	cycloheximide	—	300
31	Gestrinone	—	221
32	Hexachlorophene	—	300
33	Lynestrenol	—	299
34	Phenoxybenzamine	—	21
35	Pueraria	—	300
36	Digoxin	—	299
37	Progesterone	—	299
38	propyl gallate	—	261
39	Celecoxib	—	295
40	Equilin	—	216
41	Pregnenolone	—	300
42	Quinestrol	—	194
43	Androstenedione	—	300
44	Clotrimazole	—	296
45	Ethylestrenol	—	70
46	Methandrostenolone	—	300
47	Testosterone	—	299
48	17-alpha-Hydroxyprogesterone	—	300
49	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
50	Emetine	—	298

About the Regulation of RUNX2 expression and activity Pathway

The Regulation of RUNX2 expression and activity pathway is catalogued in Reactome (ID: R-HSA-8939902) and involves 40 genes. In the BiohacksAI corpus, 396 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CBFB, CUL1, ESR1, ESRRA.