What genes are in the EML4 and NUDC in mitotic spindle formation pathway?

The EML4 and NUDC in mitotic spindle formation pathway involves 29 genes. Key genes include: AURKB, BIRC5, EML4, NEK6, NEK7, NEK9, PLK1, PPP1CC, PPP2CA, PPP2R5A.

EML4 and NUDC in mitotic spindle formation

Q: What compounds affect the EML4 and NUDC in mitotic spindle formation pathway?

43 compounds in the BiohacksAI corpus have documented interactions with genes in the EML4 and NUDC in mitotic spindle formation pathway (Reactome ID: R-HSA-9648025). These compounds target 29 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-964802529 genes43 compounds

The EML4 and NUDC in mitotic spindle formation pathway (Reactome ID: R-HSA-9648025) involves 29 genes and is affected by 43 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AURKB BIRC5 EML4 NEK6 NEK7 NEK9 PLK1 PPP1CC PPP2CA PPP2R5A TAOK1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B XPO1

Compounds Affecting EML4 and NUDC in mitotic spindle formation

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Vincristine	—	299
4	Noscapine	—	300
5	Podophyllotoxin	—	14
6	Demecolcine	—	246
7	Maytansine	—	300
8	vinblastine sulfate	—	81
9	Vorinostat	—	299
10	Crizotinib	—	298
11	Quercetin	—	300
12	Okadaic Acid	—	300
13	Sorafenib	—	300
14	sp600125	—	117
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	Dasatinib	—	299
17	fisetin	—	78
18	Axitinib	—	298
19	kenpaullone	—	8
20	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
21	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
22	Kaempferols	—	300
23	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
24	hydroxyfasudil [Supplementary Concept]	—	11
25	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
26	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
27	scutellarein	—	113
28	tamarixetin	—	26
29	ly294002	—	11
30	Wortmannin	—	300
31	Oleic Acid	—	112
32	Simvastatin	—	1,000
33	cefaclor	—	299
34	Disulfiram	—	297
35	Hexachlorophene	—	300
36	Lithocholic Acid	—	300
37	Nisoldipine	—	297
38	Oxyphenbutazone	—	300
39	Oxytetracycline	—	300
40	plumbagin [Supplementary Concept]	—	300
41	oridonin	—	300
42	Buthionine Sulfoximine	—	300
43	Vitamin K 3	—	300

About the EML4 and NUDC in mitotic spindle formation Pathway

The EML4 and NUDC in mitotic spindle formation pathway is catalogued in Reactome (ID: R-HSA-9648025) and involves 29 genes. In the BiohacksAI corpus, 43 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AURKB, BIRC5, EML4, NEK6, NEK7.