Drug resistance in ERBB2 KD mutants
REACTOME PATHWAYThe Drug resistance in ERBB2 KD mutants pathway (Reactome ID: R-HSA-9665230) involves 3 genes and is affected by 33 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Drug resistance in ERBB2 KD mutants
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | 19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept] | — | 300 |
| 2 | celastrol | — | 300 |
| 3 | triolimus [Supplementary Concept] | — | 33 |
| 4 | monorden | — | 8 |
| 5 | gedunin | — | 54 |
| 6 | Novobiocin | — | 300 |
| 7 | caffeic acid | — | 300 |
| 8 | Masoprocol | — | 300 |
| 9 | Tetracycline | — | 300 |
| 10 | Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione. | — | 300 |
| 11 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 12 | Quercetin | — | 300 |
| 13 | 2-Chloroadenosine 2-Chloroadenosine. | — | 300 |
| 14 | Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid. | — | 300 |
| 15 | ag490 | — | 14 |
| 16 | Calcimycin | — | 216 |
| 17 | Calcitriol | — | 300 |
| 18 | Ciclopirox | — | 88 |
| 19 | Clotrimazole | — | 296 |
| 20 | cycloheximide | — | 300 |
| 21 | deguelin [Supplementary Concept] | — | 151 |
| 22 | Disulfiram | — | 297 |
| 23 | Hexachlorophene | — | 300 |
| 24 | Idarubicin | — | 299 |
| 25 | Indazoles | — | 300 |
| 26 | Miconazole | — | 298 |
| 27 | piceatannol | — | 300 |
| 28 | Nitroprusside | — | 299 |
| 29 | specioside | — | 6 |
| 30 | Wortmannin | — | 300 |
| 31 | Dasatinib | — | 299 |
| 32 | Afatinib | — | 297 |
| 33 | tyrphostin ag 1478 | — | 4 |
About the Drug resistance in ERBB2 KD mutants Pathway
The Drug resistance in ERBB2 KD mutants pathway is catalogued in Reactome (ID: R-HSA-9665230) and involves 3 genes. In the BiohacksAI corpus, 33 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC37, ERBB2, HSP90AA1.