What genes are in the Resistance of ERBB2 KD mutants to lapatinib pathway?

The Resistance of ERBB2 KD mutants to lapatinib pathway involves 3 genes. Key genes include: CDC37, ERBB2, HSP90AA1.

Resistance of ERBB2 KD mutants to lapatinib

Q: What compounds affect the Resistance of ERBB2 KD mutants to lapatinib pathway?

33 compounds in the BiohacksAI corpus have documented interactions with genes in the Resistance of ERBB2 KD mutants to lapatinib pathway (Reactome ID: R-HSA-9665251). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-96652513 genes33 compounds

The Resistance of ERBB2 KD mutants to lapatinib pathway (Reactome ID: R-HSA-9665251) involves 3 genes and is affected by 33 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC37 ERBB2 HSP90AA1

Compounds Affecting Resistance of ERBB2 KD mutants to lapatinib

#	Compound	Targets Hit	Studies
1	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
2	celastrol	—	300
3	triolimus [Supplementary Concept]	—	33
4	monorden	—	8
5	gedunin	—	54
6	Novobiocin	—	300
7	caffeic acid	—	300
8	Masoprocol	—	300
9	Tetracycline	—	300
10	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	Quercetin	—	300
13	2-Chloroadenosine 2-Chloroadenosine.	—	300
14	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
15	ag490	—	14
16	Calcimycin	—	216
17	Calcitriol	—	300
18	Ciclopirox	—	88
19	Clotrimazole	—	296
20	cycloheximide	—	300
21	deguelin [Supplementary Concept]	—	151
22	Disulfiram	—	297
23	Hexachlorophene	—	300
24	Idarubicin	—	299
25	Indazoles	—	300
26	Miconazole	—	298
27	piceatannol	—	300
28	Nitroprusside	—	299
29	specioside	—	6
30	Wortmannin	—	300
31	Dasatinib	—	299
32	Afatinib	—	297
33	tyrphostin ag 1478	—	4

About the Resistance of ERBB2 KD mutants to lapatinib Pathway

The Resistance of ERBB2 KD mutants to lapatinib pathway is catalogued in Reactome (ID: R-HSA-9665251) and involves 3 genes. In the BiohacksAI corpus, 33 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC37, ERBB2, HSP90AA1.