SARS-CoV-1 activates/modulates innate immune responses

Q: What compounds affect the SARS-CoV-1 activates/modulates innate immune responses pathway?

75 compounds in the BiohacksAI corpus have documented interactions with genes in the SARS-CoV-1 activates/modulates innate immune responses pathway (Reactome ID: R-HSA-9692916). These compounds target 11 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-969291611 genes75 compounds

The SARS-CoV-1 activates/modulates innate immune responses pathway (Reactome ID: R-HSA-9692916) involves 11 genes and is affected by 75 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASP1 FKBP1A IKBKE KPNB1 NFKB1 NFKBIA NLRP3 RELA RIPK3 RUNX1 TBK1

Compounds Affecting SARS-CoV-1 activates/modulates innate immune responses

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	Bortezomib	—	300
3	Hexachlorophene	—	300
4	Quercetin	—	300
5	Resveratrol	—	298
6	Podophyllotoxin	—	14
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Kaempferols	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Rutin	—	300
11	Withania	—	500
12	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
13	tamarixetin	—	26
14	Trifluridine	—	295
15	withaferin	—	300
16	chicoric acid	—	117
17	cycloheximide	—	300
18	Ethinyl Estradiol	—	300
19	Thioridazine	—	35
20	Chlorhexidine	—	299
21	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
22	amlexanox	—	96
23	Crizotinib	—	298
24	Hydrocortisone	—	299
25	egcg	—	300
26	Cerulenin	—	300
27	Chlorpropamide	—	300
28	daph	—	2
29	Hydrocortisone	—	298
30	Lovastatin	—	300
31	ly294002	—	11
32	Promethazine	—	121
33	protriptyline	—	296
34	streptonigrin	—	299
35	Sulfaphenazole	—	300
36	Triamcinolone	—	300
37	tyrphostin 1	—	1
38	tyrphostin ag 1478	—	4
39	Voriconazole	—	299
40	Cathelicidins Antimicrobial cationic peptides with	—	300
41	plumbagin [Supplementary Concept]	—	300
42	Ursolic Acid	—	300
43	Oleanolic Acid	—	300
44	pyrrolidine dithiocarbamate	—	275
45	vinblastine sulfate	—	81
46	Androsterone	—	300
47	Dimethyl Fumarate	—	296
48	Etiocholanolone	—	300
49	Lithocholic Acid	—	300
50	Niclosamide	—	299

About the SARS-CoV-1 activates/modulates innate immune responses Pathway

The SARS-CoV-1 activates/modulates innate immune responses pathway is catalogued in Reactome (ID: R-HSA-9692916) and involves 11 genes. In the BiohacksAI corpus, 75 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP1, FKBP1A, IKBKE, KPNB1, NFKB1.