What genes are in the STAT3 nuclear events downstream of ALK signaling pathway?

The STAT3 nuclear events downstream of ALK signaling pathway involves 7 genes. Key genes include: DNMT1, EP300, HDAC1, HDAC2, HDAC3, HIF1A, STAT3.

STAT3 nuclear events downstream of ALK signaling

Q: What compounds affect the STAT3 nuclear events downstream of ALK signaling pathway?

68 compounds in the BiohacksAI corpus have documented interactions with genes in the STAT3 nuclear events downstream of ALK signaling pathway (Reactome ID: R-HSA-9701898). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-97018987 genes68 compounds

The STAT3 nuclear events downstream of ALK signaling pathway (Reactome ID: R-HSA-9701898) involves 7 genes and is affected by 68 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

DNMT1 EP300 HDAC1 HDAC2 HDAC3 HIF1A STAT3

Compounds Affecting STAT3 nuclear events downstream of ALK signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Camptothecin	—	300
3	Celecoxib	—	295
4	egcg	—	300
5	Vorinostat	—	299
6	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
7	scriptaid	—	53
8	Valproic Acid	—	296
9	pictilisib	—	25
10	Butyric Acid	—	300
11	Ursolic Acid	—	300
12	Daunorubicin	—	298
13	Niclosamide	—	299
14	Oxytetracycline	—	300
15	Emetine	—	298
16	cycloheximide	—	300
17	Topotecan	—	300
18	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
19	Gliotoxin	—	300
20	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
21	Harmaline	—	300
22	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
23	Loratadine	—	296
24	oxatomide [Supplementary Concept] structure;	—	128
25	triolimus [Supplementary Concept]	—	33
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	chrysin	—	300
28	Hydrocortisone	—	299
29	Kaempferols	—	300
30	Quercetin	—	300
31	Resveratrol	—	298
32	2-Chloroadenosine 2-Chloroadenosine.	—	300
33	ag490	—	14
34	Beclomethasone	—	300
35	celastrol	—	300
36	Clotrimazole	—	296
37	cycloserine	—	298
38	Dequalinium	—	136
39	Desoximetasone	—	86
40	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
41	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
42	Digoxin	—	299
43	Epinephrine	—	299
44	Ethoxyquin Antioxidant; also	—	180
45	Fusaric Acid	—	300
46	gedunin	—	54
47	Hesperidin	—	300
48	Hydrocortisone	—	298
49	Mometasone Furoate	—	292
50	Nisoldipine	—	297

About the STAT3 nuclear events downstream of ALK signaling Pathway

The STAT3 nuclear events downstream of ALK signaling pathway is catalogued in Reactome (ID: R-HSA-9701898) and involves 7 genes. In the BiohacksAI corpus, 68 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DNMT1, EP300, HDAC1, HDAC2, HDAC3.