What genes are in the NPAS4 regulates expression of target genes pathway?

The NPAS4 regulates expression of target genes pathway involves 13 genes. Key genes include: ARNT, CDK5, CDK5R1, CREBBP, FOS, GEM, INS, MAPK1, MAPK3, MDM2.

NPAS4 regulates expression of target genes

Q: What compounds affect the NPAS4 regulates expression of target genes pathway?

100 compounds in the BiohacksAI corpus have documented interactions with genes in the NPAS4 regulates expression of target genes pathway (Reactome ID: R-HSA-9768919). These compounds target 13 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-976891913 genes100 compounds

The NPAS4 regulates expression of target genes pathway (Reactome ID: R-HSA-9768919) involves 13 genes and is affected by 100 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARNT CDK5 CDK5R1 CREBBP FOS GEM INS MAPK1 MAPK3 MDM2 PLK2 RET XPO1

Compounds Affecting NPAS4 regulates expression of target genes

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	alsterpaullone	—	12
3	kenpaullone	—	8
4	Sorafenib	—	300
5	plumbagin [Supplementary Concept]	—	300
6	fisetin	—	78
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Digoxin	—	299
9	Calcimycin	—	216
10	Colchicine	—	300
11	Nocodazole Nocodazole is	—	215
12	streptonigrin	—	299
13	Thioridazine	—	35
14	pd98059	—	7
15	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
16	trametinib	—	296
17	withaferin	—	300
18	indirubin	—	300
19	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
20	chrysin	—	300
21	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
22	egcg	—	300
23	cycloheximide	—	300
24	Cytarabine	—	297
25	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
26	Niclosamide	—	299
27	Tubercidin	—	300
28	Anisomycin	—	247
29	Astemizole Antihistamine drug now withdrawn from	—	280
30	Azacitidine	—	298
31	Azacitidine	—	300
32	Chlorhexidine	—	299
33	Ciclopirox	—	88
34	Cladribine	—	297
35	colchine	—	2
36	Demecolcine	—	246
37	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
38	Fluspirilene	—	74
39	gedunin	—	54
40	Hexachlorophene	—	300
41	lidoflazine	—	278
42	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
43	Nisoldipine	—	297
44	Ouabain	—	300
45	paxilline	—	42
46	Podophyllotoxin	—	14
47	rafoxanide	—	172
48	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
49	Trifluridine	—	295
50	tyrphostin 9	—	2

About the NPAS4 regulates expression of target genes Pathway

The NPAS4 regulates expression of target genes pathway is catalogued in Reactome (ID: R-HSA-9768919) and involves 13 genes. In the BiohacksAI corpus, 100 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARNT, CDK5, CDK5R1, CREBBP, FOS.