What compounds affect the NFE2L2 regulating tumorigenic genes pathway?

213 compounds in the BiohacksAI corpus have documented interactions with genes in the NFE2L2 regulating tumorigenic genes pathway (Reactome ID: R-HSA-9818030). These compounds target 4 genes within this pathway.

What genes are in the NFE2L2 regulating tumorigenic genes pathway?

The NFE2L2 regulating tumorigenic genes pathway involves 4 genes. Key genes include: BCL2L1, CREBBP, EP300, NFE2L2.

NFE2L2 regulating tumorigenic genes

REACTOME PATHWAY

Reactome: R-HSA-98180304 genes213 compounds

The NFE2L2 regulating tumorigenic genes pathway (Reactome ID: R-HSA-9818030) involves 4 genes and is affected by 213 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BCL2L1 CREBBP EP300 NFE2L2

Compounds Affecting NFE2L2 regulating tumorigenic genes

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	vinblastine sulfate	—	81
3	Nocodazole Nocodazole is	—	215
4	Masoprocol	—	300
5	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
6	Papaverine	—	299
7	Resveratrol	—	298
8	Vitamin	—	295
9	Azacitidine	—	298
10	Azacitidine	—	300
11	Genistein	—	300
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	alpha-Linolenic Acid	—	300
14	Oxymetholone	—	298
15	Rotenone	—	300
16	Methylene Blue	—	200
17	Ethoxyquin Antioxidant; also	—	180
18	Nitrofurazone	—	300
19	Quercetin	—	300
20	Azathioprine	—	300
21	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
22	Mestranol	—	300
23	methoprene	—	300
24	Niclosamide	—	299
25	Phenelzine	—	2
26	chrysin	—	300
27	alyssin [Supplementary Concept]	—	300
28	Digitoxin	—	300
29	Digoxin	—	299
30	Flutamide	—	298
31	Hexachlorophene	—	300
32	Linoleic Acid	—	300
33	Vitamin K 3	—	300
34	Nitrofurantoin	—	297
35	Ouabain	—	300
36	Podophyllotoxin	—	14
37	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
38	Toxaphene	—	299
39	DEAD-box RNA Helicases	—	169
40	Thioctic Acid	—	298
41	amlexanox	—	96
42	Bortezomib	—	300
43	Chlormadinone Acetate	—	300
44	Ethidium	—	300
45	Feprazone	—	63
46	Idazoxan	—	300
47	Leflunomide	—	297
48	Oxyphenbutazone	—	300
49	Thioctic Acid	—	300
50	Caffeine	—	299

About the NFE2L2 regulating tumorigenic genes Pathway

The NFE2L2 regulating tumorigenic genes pathway is catalogued in Reactome (ID: R-HSA-9818030) and involves 4 genes. In the BiohacksAI corpus, 213 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BCL2L1, CREBBP, EP300, NFE2L2.