What compounds affect the Mitochondrial protein degradation pathway?

58 compounds in the BiohacksAI corpus have documented interactions with genes in the Mitochondrial protein degradation pathway (Reactome ID: R-HSA-9837999). These compounds target 14 genes within this pathway.

What genes are in the Mitochondrial protein degradation pathway?

The Mitochondrial protein degradation pathway involves 14 genes. Key genes include: ALDH2, APP, COX1, COX2, DLD, ECH1, FECH, FH, HSPD1, LONP1.

Mitochondrial protein degradation

REACTOME PATHWAY

Reactome: R-HSA-983799914 genes58 compounds

The Mitochondrial protein degradation pathway (Reactome ID: R-HSA-9837999) involves 14 genes and is affected by 58 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALDH2 APP COX1 COX2 DLD ECH1 FECH FH HSPD1 LONP1 MDH2 PDK1 PRKACA SHMT2

Compounds Affecting Mitochondrial protein degradation

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	Disulfiram	—	297
3	streptonigrin	—	299
4	Aurintricarboxylic Acid	—	184
5	fisetin	—	78
6	Oxaprozin	—	181
7	Resveratrol	—	298
8	Quercetin	—	300
9	Hesperidin	—	300
10	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
11	Kaempferols	—	300
12	Methylene Blue	—	200
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses	—	300
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	caffeic acid	—	300
17	Vitamin	—	295
18	2-Methoxyestradiol	—	300
19	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
20	Cladribine	—	297
21	Digitoxin	—	300
22	Digoxin	—	299
23	Edetic Acid	—	24
24	Catechin	—	300
25	Vanillic Acid	—	300
26	Ouabain	—	300
27	Podophyllotoxin	—	14
28	Quinic Acid	—	218
29	Retinaldehyde	—	300
30	Trifluridine	—	295
31	Arachidonic Acid	—	245
32	plumbagin [Supplementary Concept]	—	300
33	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
34	Adapalene	—	296
35	Evans Blue	—	300
36	Hexachlorophene	—	300
37	Lithocholic Acid	—	300
38	rafoxanide	—	172
39	Suramin	—	300
40	Cisplatin	—	300
41	Iodoacetamide	—	300
42	piceatannol	—	300
43	Rutin	—	300
44	Pioglitazone	—	297
45	Pueraria	—	300
46	prunetin	—	35
47	Duloxetine Hydrochloride	—	993
48	Papaverine	—	299
49	chrysin	—	300
50	Vemurafenib	—	298

About the Mitochondrial protein degradation Pathway

The Mitochondrial protein degradation pathway is catalogued in Reactome (ID: R-HSA-9837999) and involves 14 genes. In the BiohacksAI corpus, 58 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALDH2, APP, COX1, COX2, DLD.