Regulation of PD-L1(CD274) Post-translational modification

Q: What compounds affect the Regulation of PD-L1(CD274) Post-translational modification pathway?

57 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of PD-L1(CD274) Post-translational modification pathway (Reactome ID: R-HSA-9909615). These compounds target 50 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-990961550 genes57 compounds

The Regulation of PD-L1(CD274) Post-translational modification pathway (Reactome ID: R-HSA-9909615) involves 50 genes and is affected by 57 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CDK4 COPS5 CSNK2A1 CSNK2A2 CSNK2B CUL1 GSK3B NEK2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7+20 more

Compounds Affecting Regulation of PD-L1(CD274) Post-translational modification

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Ursolic Acid	—	300
4	Oleanolic Acid	—	300
5	Quercetin	—	300
6	Adenosine Monophosphate Adenine nucleotide containing	—	300
7	Proguanil	—	299
8	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
9	Niclosamide	—	299
10	Berberine	—	300
11	Antimycin	—	300
12	Rotenone	—	300
13	Metformin	—	1,000
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
16	Kaempferols	—	300
17	chrysin	—	300
18	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
19	fisetin	—	78
20	ly294002	—	11
21	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
22	egcg	—	300
23	sp600125	—	117
24	Vanillic Acid	—	300
25	alsterpaullone	—	12
26	kenpaullone	—	8
27	indirubin	—	300
28	Rutin	—	300
29	ninhydrin	—	300
30	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
31	Lithium Chloride	—	300
32	Sorafenib	—	300
33	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
34	Dichlororibofuranosylbenzimidazole	—	26
35	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
36	pictilisib	—	25
37	Axitinib	—	298
38	Disulfiram	—	297
39	4-Hydroxybenzoate-3-Monooxygenase	—	300
40	Genistein	—	300
41	Crizotinib	—	298
42	Hexachlorophene	—	300
43	Oxytetracycline	—	300
44	Clotrimazole	—	296
45	Demeclocycline	—	5
46	Edaravone	—	298
47	DEAD-box RNA Helicases	—	169
48	Thioctic Acid	—	298
49	Sphingosine	—	300
50	Thioctic Acid	—	300

About the Regulation of PD-L1(CD274) Post-translational modification Pathway

The Regulation of PD-L1(CD274) Post-translational modification pathway is catalogued in Reactome (ID: R-HSA-9909615) and involves 50 genes. In the BiohacksAI corpus, 57 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CDK4, COPS5, CSNK2A1, CSNK2A2.