What genes are in the Developmental Lineage of Pancreatic Acinar Cells pathway?

The Developmental Lineage of Pancreatic Acinar Cells pathway involves 4 genes. Key genes include: GNMT, PLA2G1B, PNLIP, PRSS1.

Developmental Lineage of Pancreatic Acinar Cells

Q: What compounds affect the Developmental Lineage of Pancreatic Acinar Cells pathway?

45 compounds in the BiohacksAI corpus have documented interactions with genes in the Developmental Lineage of Pancreatic Acinar Cells pathway (Reactome ID: R-HSA-9925561). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-99255614 genes45 compounds

The Developmental Lineage of Pancreatic Acinar Cells pathway (Reactome ID: R-HSA-9925561) involves 4 genes and is affected by 45 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GNMT PLA2G1B PNLIP PRSS1

Compounds Affecting Developmental Lineage of Pancreatic Acinar Cells

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
3	Crizotinib	—	298
4	Calcimycin	—	216
5	Dequalinium	—	136
6	Ticagrelor	—	299
7	tyrphostin ag 1478	—	4
8	Aurintricarboxylic Acid	—	184
9	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
10	Chlorhexidine	—	299
11	Cisplatin	—	300
12	darapladib [Supplementary Concept]	—	44
13	Dasatinib	—	299
14	Demeclocycline	—	297
15	Iodoacetamide	—	300
16	pictilisib	—	25
17	Vemurafenib	—	298
18	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
19	Thyroxine	—	994
20	2-Methoxyestradiol	—	300
21	Afatinib	—	297
22	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
23	Disulfiram	—	297
24	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
25	Estrone	—	300
26	Guanabenz	—	298
27	Methyldopa	—	297
28	Methylergonovine	—	193
29	Methysergide	—	300
30	piceatannol	—	300
31	propionylpromazine hydrochloride	—	2
32	scriptaid	—	53
33	Suramin	—	300
34	Thiorphan	—	300
35	Thyroxine	—	300
36	Triiodothyronine	—	300
37	tyrphostin 9	—	2
38	Chenodeoxycholic Acid	—	299
39	Cholic Acid	—	299
40	Hexachlorophene	—	300
41	Oleanolic Acid	—	300
42	Taurodeoxycholic Acid	—	300
43	rafoxanide	—	172
44	Bortezomib	—	300
45	Sulfaguanidine	—	255

About the Developmental Lineage of Pancreatic Acinar Cells Pathway

The Developmental Lineage of Pancreatic Acinar Cells pathway is catalogued in Reactome (ID: R-HSA-9925561) and involves 4 genes. In the BiohacksAI corpus, 45 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GNMT, PLA2G1B, PNLIP, PRSS1.