Developmental Lineage of Mammary Gland Alveolar Cells

Q: What compounds affect the Developmental Lineage of Mammary Gland Alveolar Cells pathway?

337 compounds in the BiohacksAI corpus have documented interactions with genes in the Developmental Lineage of Mammary Gland Alveolar Cells pathway (Reactome ID: R-HSA-9927426). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-99274264 genes337 compounds

The Developmental Lineage of Mammary Gland Alveolar Cells pathway (Reactome ID: R-HSA-9927426) involves 4 genes and is affected by 337 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ESR1 KIT MUC1 PGR

Compounds Affecting Developmental Lineage of Mammary Gland Alveolar Cells

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Axitinib	—	298
3	Dasatinib	—	299
4	Levonorgestrel	—	292
5	Norgestrel	—	300
6	Resveratrol	—	298
7	Ethinyl Estradiol	—	300
8	Genistein	—	300
9	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
10	Methyltestosterone	—	300
11	Dehydroepiandrosterone	—	300
12	Dehydroepiandrosterone	—	300
13	Fulvestrant	—	295
14	Kaempferols	—	300
15	Dactinomycin	—	297
16	Danazol	—	298
17	Estrone	—	300
18	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
19	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
20	Rotenone	—	300
21	Dihydrotestosterone	—	300
22	Ethidium	—	300
23	Ethynodiol Diacetate	—	300
24	Flutamide	—	298
25	Estriol	—	300
26	Mestranol	—	300
27	Norethindrone	—	300
28	Oxymetholone	—	298
29	Testosterone Propionate	—	300
30	cycloheximide	—	300
31	Gestrinone	—	221
32	Hexachlorophene	—	300
33	Lynestrenol	—	299
34	Phenoxybenzamine	—	21
35	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
36	Progesterone	—	299
37	Bortezomib	—	300
38	Niclosamide	—	299
39	Triiodothyronine	—	300
40	vinblastine sulfate	—	81
41	Celecoxib	—	295
42	Equilin	—	216
43	Loratadine	—	296
44	Methylcholanthrene	—	300
45	Masoprocol	—	300
46	Pregnenolone	—	300
47	Quinestrol	—	194
48	Quercetin	—	300
49	Adapalene	—	296
50	Androstenedione	—	300

About the Developmental Lineage of Mammary Gland Alveolar Cells Pathway

The Developmental Lineage of Mammary Gland Alveolar Cells pathway is catalogued in Reactome (ID: R-HSA-9927426) and involves 4 genes. In the BiohacksAI corpus, 337 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ESR1, KIT, MUC1, PGR.