A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
Hydroxyzine has been studied across 14 research domains including 😴 Sleep, 🧘 Stress & Anxiety, 💊 Pain, ✨ Skin & Hair, 🧠 Focus & Attention. The primary research focus is 😴 Sleep with 22% of studies addressing this area.
The following compounds share molecular targets with Hydroxyzine, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.
This evidence profile for Hydroxyzine is generated deterministically from 298 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.