What compounds target CHRM3?

BiohacksAI has identified 39 compounds that interact with CHRM3 (cholinergic receptor muscarinic 3). Top compounds include: Hyoscyamine, N-Methylscopolamine, Arecoline, Pilocarpine, Scopolamine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CHRM3 (cholinergic receptor muscarinic)?

CHRM3 is cholinergic receptor muscarinic 3. It is a molecular target for 39 compounds documented in PubMed bioassay data. UniProt ID: P20309. NCBI Gene ID: 1131.

CHRM3

MOLECULAR TARGET

cholinergic receptor muscarinic 3

UniProt: P20309 NCBI Gene: 113139 compounds

CHRM3 (cholinergic receptor muscarinic 3) is targeted by 39 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CHRM3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Hyoscyamine	4.20	66
2	N-Methylscopolamine	3.78	43
3	Arecoline	3.74	41
4	Pilocarpine	2.89	17
5	Scopolamine	2.30	9
6	Muscarine	1.79	5
7	Hyoscyamine	1.61	4
8	Ipratropium	1.61	4
9	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.39	3
10	Quetiapine Fumarate	1.10	2
11	hexahydrosiladiphenidol	1.10	2
12	Strychnine	1.10	2
13	Tolterodine Tartrate	1.10	2
14	Fluoxetine	0.69	1
15	Mianserin	0.69	1
16	Amoxapine	0.69	1
17	Astemizole Antihistamine drug now withdrawn from	0.69	1
18	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	0.69	1
19	Butaclamol	0.69	1
20	Chlorhexidine	0.69	1
21	Cyclacillin	0.69	1
22	Cyproheptadine	0.69	1
23	dilazep	0.69	1
24	Dimethindene	0.69	1
25	Fentanyl	0.69	1
26	Fluspirilene	0.69	1
27	Loxapine	0.69	1
28	Maprotiline	0.69	1
29	Metergoline	0.69	1
30	Nefopam Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for	0.69	1
31	Nortriptyline	0.69	1
32	oxatomide [Supplementary Concept] structure;	0.69	1
33	Promethazine	0.69	1
34	protriptyline	0.69	1
35	Tilorone	0.69	1
36	Tiotropium Bromide	0.69	1
37	Valproic Acid	0.69	1
38	Vemurafenib	0.69	1
39	Vincamine	0.69	1

About CHRM3 as a Drug Target

CHRM3 (cholinergic receptor muscarinic 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 39 compounds with documented CHRM3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CHRM3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.