What compounds target CYP2D6?

BiohacksAI has identified 324 compounds that interact with CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)). Top compounds include: Quinidine, Yohimbine, Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of, Chlorhexidine, Cyproheptadine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CYP2D6 (cytochrome P450 family)?

CYP2D6 is cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene). It is a molecular target for 324 compounds documented in PubMed bioassay data. UniProt ID: ANW61984. NCBI Gene ID: 1565.

CYP2D6

MOLECULAR TARGET

cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)

UniProt: ANW61984 NCBI Gene: 1565324 compounds

CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)) is targeted by 324 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CYP2D6

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Quinidine	4.33	75
2	Yohimbine	2.48	11
3	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	2.40	10
4	Chlorhexidine	2.30	9
5	Cyproheptadine	2.30	9
6	Maprotiline	2.30	9
7	Methoxsalen	2.30	9
8	Oxymetazoline	2.30	9
9	Nortriptyline	2.20	8
10	Kaempferols	2.08	7
11	Amoxapine	2.08	7
12	Astemizole Antihistamine drug now withdrawn from	2.08	7
13	Celecoxib	2.08	7
14	Danazol	2.08	7
15	Fluspirilene	2.08	7
16	Loratadine	2.08	7
17	Perphenazine	2.08	7
18	Piribedil	2.08	7
19	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	2.08	7
20	Timolol	2.08	7
21	Tolazamide	2.08	7
22	Buspirone	1.95	6
23	Clotrimazole	1.95	6
24	Domperidone	1.95	6
25	doxylamine succinate	1.95	6
26	Ethoxyquin Antioxidant; also	1.95	6
27	Phentolamine	1.95	6
28	Piperonyl Butoxide	1.95	6
29	Methylene Blue	1.79	5
30	Progesterone	1.79	5
31	Cimetidine	1.79	5
32	clofilium tosylate	1.79	5
33	Clonidine	1.79	5
34	Physostigmine	1.79	5
35	Ethidium	1.79	5
36	lidoflazine	1.79	5
37	Melphalan	1.79	5
38	Vitamin K 3	1.79	5
39	Metoclopramide	1.79	5
40	Miconazole	1.79	5
41	Niacin	1.79	5
42	oxatomide [Supplementary Concept] structure;	1.79	5
43	Phenelzine	1.79	5
44	Physostigmine	1.79	5
45	Propantheline	1.79	5
46	Reserpine	1.79	5
47	Sulindac	1.79	5
48	Tetracycline	1.79	5
49	Vincamine	1.79	5
50	Duloxetine Hydrochloride	1.61	4

Showing top 50 of 324 compounds. Use the BiohacksAI search to explore all CYP2D6 modulators.

About CYP2D6 as a Drug Target

CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 324 compounds with documented CYP2D6 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CYP2D6 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.