What compounds target ESR2?

BiohacksAI has identified 111 compounds that interact with ESR2 (estrogen receptor 2). Top compounds include: Genistein, Fulvestrant, Estrone, Pueraria, Ethinyl Estradiol. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ESR2 (estrogen receptor 2)?

ESR2 is estrogen receptor 2. It is a molecular target for 111 compounds documented in PubMed bioassay data. UniProt ID: Q92731. NCBI Gene ID: 2100.

ESR2

MOLECULAR TARGET

estrogen receptor 2

UniProt: Q92731 NCBI Gene: 2100111 compounds

ESR2 (estrogen receptor 2) is targeted by 111 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ESR2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Genistein	3.74	41
2	Fulvestrant	3.18	23
3	Estrone	3.04	20
4	Pueraria	2.56	12
5	Ethinyl Estradiol	2.30	9
6	Apigenin 5,7,4'-trihydroxy-flavone,	2.08	7
7	Dehydroepiandrosterone	2.08	7
8	Resveratrol	2.08	7
9	Dehydroepiandrosterone	2.08	7
10	Kaempferols	1.79	5
11	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	1.79	5
12	Estriol	1.79	5
13	Norethindrone	1.79	5
14	Rotenone	1.79	5
15	Androstenediol	1.61	4
16	Mestranol	1.61	4
17	Methyltestosterone	1.61	4
18	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	1.61	4
19	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	1.39	3
20	Azacitidine	1.39	3
21	Azacitidine	1.39	3
22	Dactinomycin	1.39	3
23	Dihydrotestosterone	1.39	3
24	Estetrol	1.39	3
25	Lynestrenol	1.39	3
26	Medroxyprogesterone Acetate	1.39	3
27	Nisoldipine	1.39	3
28	Pregnenolone	1.39	3
29	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	1.39	3
30	Budesonide	1.10	2
31	Progesterone	1.10	2
32	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	1.10	2
33	Testosterone	1.10	2
34	Beclomethasone	1.10	2
35	Chlorhexidine	1.10	2
36	Ciclopirox	1.10	2
37	Clotrimazole	1.10	2
38	Danazol	1.10	2
39	Daunorubicin	1.10	2
40	Deferasirox	1.10	2
41	Dimethisterone	1.10	2
42	Emetine	1.10	2
43	Equilin	1.10	2
44	Estramustine	1.10	2
45	Ethidium	1.10	2
46	Ethylestrenol	1.10	2
47	Ethynodiol Diacetate	1.10	2
48	Flutamide	1.10	2
49	Methandrostenolone	1.10	2
50	o-Phthalaldehyde	1.10	2

Showing top 50 of 111 compounds. Use the BiohacksAI search to explore all ESR2 modulators.

About ESR2 as a Drug Target

ESR2 (estrogen receptor 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 111 compounds with documented ESR2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ESR2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.