BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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Estetrol

A metabolite of ESTRIOL with a 15-alpha-hydroxyl group. Estetrol can be converted from estriol sulfate or DEHYDROEPIANDROSTERONE SULFATE by the fetal-placental unit.

266+ PubMed studies analyzed · 21 RCTs · Evidence Score: 45

Research Domains

Estetrol has been studied across 20 research domains including 🧬 Hormones, 🔬 Oncology, 💪 Strength & Power, 😴 Sleep, 🫁 Liver & Detox. The primary research focus is 🧬 Hormones with 60% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Estetrol, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Androstenediol
2 shared targets
Estriol
2 shared targets
Stanozolol
2 shared targets
Fulvestrant
2 shared targets
Norethindrone
2 shared targets
Spironolactone
2 shared targets
Mestranol
2 shared targets
Estrone
2 shared targets
Testosterone
2 shared targets
Medroxyprogesterone
2 shared targets
Loading evidence profile...

This evidence profile for Estetrol is generated deterministically from 266 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.