What compounds target HTR1B?

BiohacksAI has identified 32 compounds that interact with HTR1B (5-hydroxytryptamine receptor 1B). Top compounds include: Sumatriptan, Quipazine, Mianserin, Metergoline, Ergotamine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HTR1B (5-hydroxytryptamine receptor 1B)?

HTR1B is 5-hydroxytryptamine receptor 1B. It is a molecular target for 32 compounds documented in PubMed bioassay data. UniProt ID: P28564. NCBI Gene ID: 25075.

HTR1B

MOLECULAR TARGET

5-hydroxytryptamine receptor 1B

UniProt: P28564 NCBI Gene: 2507532 compounds

HTR1B (5-hydroxytryptamine receptor 1B) is targeted by 32 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HTR1B

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Sumatriptan	3.50	32
2	Quipazine	2.30	9
3	Mianserin	1.61	4
4	Metergoline	1.61	4
5	Ergotamine	1.39	3
6	Pergolide	1.39	3
7	Pindolol	1.39	3
8	Yohimbine	1.39	3
9	Aripiprazole	1.10	2
10	Bufotenin	1.10	2
11	Dihydroergotamine	1.10	2
12	Dihydroergotamine	1.10	2
13	Lisuride	1.10	2
14	Mescaline Hallucinogenic alkaloid isolated from	1.10	2
15	Methysergide	1.10	2
16	Oxymetazoline	1.10	2
17	Fluoxetine	0.69	1
18	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	0.69	1
19	brl 15572	0.69	1
20	Bromocriptine	0.69	1
21	Buspirone	0.69	1
22	Cabergoline	0.69	1
23	Cyproheptadine	0.69	1
24	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	0.69	1
25	Metoclopramide	0.69	1
26	Nortriptyline	0.69	1
27	Ondansetron	0.69	1
28	pirenperone	0.69	1
29	Pramipexole	0.69	1
30	Propranolol	0.69	1
31	Tamsulosin	0.69	1
32	Vortioxetine	0.69	1

About HTR1B as a Drug Target

HTR1B (5-hydroxytryptamine receptor 1B) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 32 compounds with documented HTR1B interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HTR1B inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.