What compounds target KAPPA-TYPE?

BiohacksAI has identified 60 compounds that interact with KAPPA-TYPE (Kappa-type opioid receptor (human)). Top compounds include: Morphine, Clotrimazole, Econazole, Astemizole Antihistamine drug now withdrawn from, Disulfiram. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is KAPPA-TYPE (Kappa-type opioid receptor)?

KAPPA-TYPE is Kappa-type opioid receptor (human). It is a molecular target for 60 compounds documented in PubMed bioassay data. UniProt ID: P41145.

KAPPA-TYPE

MOLECULAR TARGET

Kappa-type opioid receptor (human)

UniProt: P4114560 compounds

KAPPA-TYPE (Kappa-type opioid receptor (human)) is targeted by 60 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting KAPPA-TYPE

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Morphine	1.95	6
2	Clotrimazole	1.39	3
3	Econazole	1.39	3
4	Astemizole Antihistamine drug now withdrawn from	1.10	2
5	Disulfiram	1.10	2
6	Domperidone	1.10	2
7	Levorphanol	1.10	2
8	Miconazole	1.10	2
9	Nalbuphine	1.10	2
10	Naloxone	1.10	2
11	Ritonavir	1.10	2
12	Mianserin	0.69	1
13	Quetiapine Fumarate	0.69	1
14	Sertraline	0.69	1
15	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	0.69	1
16	Amoxapine	0.69	1
17	Aprindine	0.69	1
18	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	0.69	1
19	Butorphanol	0.69	1
20	Chlorhexidine	0.69	1
21	Cilostazol	0.69	1
22	Clonidine	0.69	1
23	Codeine	0.69	1
24	Cyproterone	0.69	1
25	Danazol	0.69	1
26	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	0.69	1
27	Dibucaine	0.69	1
28	Encainide	0.69	1
29	Physostigmine	0.69	1
30	Etorphine	0.69	1
31	Fentanyl	0.69	1
32	Flecainide	0.69	1
33	Fluspirilene	0.69	1
34	Guanfacine	0.69	1
35	hydrocodone	0.69	1
36	Hydroxyzine	0.69	1
37	isoetharine	0.69	1
38	lidoflazine	0.69	1
39	Loratadine	0.69	1
40	Loxapine	0.69	1
41	Lynestrenol	0.69	1
42	Meclizine	0.69	1
43	Meperidine	0.69	1
44	Nebivolol	0.69	1
45	Nefopam Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for	0.69	1
46	Nortriptyline	0.69	1
47	Nylidrin	0.69	1
48	Oxycodone	0.69	1
49	Perphenazine	0.69	1
50	Phentolamine	0.69	1

Showing top 50 of 60 compounds. Use the BiohacksAI search to explore all KAPPA-TYPE modulators.

About KAPPA-TYPE as a Drug Target

KAPPA-TYPE (Kappa-type opioid receptor (human)) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 60 compounds with documented KAPPA-TYPE interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

KAPPA-TYPE inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.