BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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BiohacksAI/Conditions/Anxiety
CONDITION

Evidence-Based Compounds for Anxiety

Anxiety disorders involve hyperactivation of the amygdala, dysregulated GABA and glutamate balance, and chronic HPA axis activation. Evidence-based compounds targeting GABA-A receptors, cortisol signalling, and serotonin pathways show clinical evidence for reducing anxiety severity, physiological stress markers, and perceived anxiety across multiple study designs.

CORTISOL STRESS pathway →DOPAMINE SEROTONIN pathway →CALCIUM SIGNALING pathway →
Top 5 Compounds — Ranked by Evidence
Weighted ranking: BiohacksAI discovery score · pathway overlap · PubMed study count
1
Cbdfeatured
298+
studies
2
Inositolfeatured
300+
studies
3
L-Theaninefeatured
299+
studies
4
Magnesiumfeatured
293+
studies
5
Rhodiola Roseafeatured
300+
studies
Ranking Methodology
Compounds are ranked using a four-signal weighted model: BiohacksAI discovery score (cross-study convergence across targets), target match (direct overlap with GABRA1, GABRA2, NR3C1 and related targets — highest differentiating signal), pathway overlap with CORTISOL STRESS and DOPAMINE SEROTONIN pathways, and PubMed study count (log-scaled). Clinical drugs are excluded.
Key Biological Targets
GABRA1GABRA2NR3C1SLC6A4CRHR1

Click a target to see all compounds with documented interactions in the BiohacksAI corpus.

Related Health Goals
Best compounds for stress →Best compounds for sleep →Best compounds for mood →
Related Conditions
DepressionInsomniaChronic Stress

This page presents computational analysis of published research from PubMed/NCBI, BindingDB, and Reactome. Rankings are based on BiohacksAI discovery score, pathway overlap, and study count. This is not medical advice — consult a healthcare professional before starting any supplement.

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