BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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BiohacksAI/Conditions/Insomnia
CONDITION

Evidence-Based Compounds for Insomnia

Insomnia affects an estimated 10–30% of adults and is driven by dysregulation of circadian rhythm, GABA signalling, cortisol excess, and melatonin deficiency. Research from over 1 million PubMed studies identifies compounds that improve sleep onset latency, sleep efficiency, and sleep architecture without the dependency risks of pharmaceutical hypnotics.

CIRCADIAN pathway →CORTISOL STRESS pathway →DOPAMINE SEROTONIN pathway →
Top 7 Compounds — Ranked by Evidence
Weighted ranking: BiohacksAI discovery score · pathway overlap · PubMed study count
1
Apigeninfeatured
300+
studies
2
Glycinefeatured
300+
studies
3
L-Theaninefeatured
299+
studies
4
Magnesiumfeatured
293+
studies
5
Melatoninfeatured
297+
studies
6
Phosphatidylserinefeatured
nootropic
7
Tryptophanfeatured
300+
studies
Ranking Methodology
Compounds are ranked using a four-signal weighted model: BiohacksAI discovery score (cross-study convergence across targets), target match (direct overlap with GABRA1, GABRA2, NR1D1 and related targets — highest differentiating signal), pathway overlap with CIRCADIAN and CORTISOL STRESS pathways, and PubMed study count (log-scaled). Clinical drugs are excluded.
Key Biological Targets
GABRA1GABRA2NR1D1ADORA2AHTR2A

Click a target to see all compounds with documented interactions in the BiohacksAI corpus.

Related Health Goals
Best compounds for sleep →Best compounds for stress →
Related Conditions
AnxietyChronic StressDepression

This page presents computational analysis of published research from PubMed/NCBI, BindingDB, and Reactome. Rankings are based on BiohacksAI discovery score, pathway overlap, and study count. This is not medical advice — consult a healthcare professional before starting any supplement.

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