What compounds affect the MAPK3 (ERK1) activation pathway?

43 compounds in the BiohacksAI corpus have documented interactions with genes in the MAPK3 (ERK1) activation pathway (Reactome ID: R-HSA-110056). These compounds target 6 genes within this pathway.

What genes are in the MAPK3 (ERK1) activation pathway?

The MAPK3 (ERK1) activation pathway involves 6 genes. Key genes include: CDK1, IL6, JAK2, MAP2K1, MAPK3, TYK2.

MAPK3 (ERK1) activation

REACTOME PATHWAY

Reactome: R-HSA-1100566 genes43 compounds

The MAPK3 (ERK1) activation pathway (Reactome ID: R-HSA-110056) involves 6 genes and is affected by 43 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK1 IL6 JAK2 MAP2K1 MAPK3 TYK2

Compounds Affecting MAPK3 (ERK1) activation

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	kenpaullone	—	8
3	alsterpaullone	—	12
4	sp600125	—	117
5	Dasatinib	—	299
6	pd98059	—	7
7	trametinib	—	296
8	Axitinib	—	298
9	indirubin	—	300
10	Clofibrate	—	299
11	Fenofibrate	—	297
12	Sertraline	—	1,000
13	Cinnarizine	—	299
14	Clotrimazole	—	296
15	Rotenone	—	300
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	chrysin	—	300
18	fisetin	—	78
19	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
20	Quercetin	—	300
21	Azauridine	—	300
22	Cladribine	—	297
23	Methylene Blue	—	200
24	2-Methoxyestradiol	—	300
25	Astemizole Antihistamine drug now withdrawn from	—	280
26	Azathioprine	—	300
27	Calcitriol	—	300
28	Camptothecin	—	300
29	Cytarabine	—	297
30	dihydrorotenone	—	13
31	Podophyllotoxin	—	14
32	streptonigrin	—	299
33	Trifluridine	—	295
34	Tripterygium	—	300
35	plumbagin [Supplementary Concept]	—	300
36	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
37	withaferin	—	300
38	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
39	Vemurafenib	—	298
40	Crizotinib	—	298
41	Methotrexate	—	289
42	pictilisib	—	25
43	Prednisolone	—	1,000

About the MAPK3 (ERK1) activation Pathway

The MAPK3 (ERK1) activation pathway is catalogued in Reactome (ID: R-HSA-110056) and involves 6 genes. In the BiohacksAI corpus, 43 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK1, IL6, JAK2, MAP2K1, MAPK3.