What compounds affect the Opioid Signalling pathway?

199 compounds in the BiohacksAI corpus have documented interactions with genes in the Opioid Signalling pathway (Reactome ID: R-HSA-111885). These compounds target 26 genes within this pathway.

What genes are in the Opioid Signalling pathway?

The Opioid Signalling pathway involves 26 genes. Key genes include: ADCY9, CAMK2B, CAMK2D, CAMKK1, CAMKK2, CDK5, CREB1, GNA15, GNAI1, GRK2.

Opioid Signalling

REACTOME PATHWAY

Reactome: R-HSA-11188526 genes199 compounds

The Opioid Signalling pathway (Reactome ID: R-HSA-111885) involves 26 genes and is affected by 199 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 CAMK2B CAMK2D CAMKK1 CAMKK2 CDK5 CREB1 GNA15 GNAI1 GRK2 MAPK1 OPRM1 PDE1A PDE1B PDE1C PDE4A PDE4B PDE4C PDE4D PLCB3 PPP1CA PPP2CA PRKACA PRKACB PRKACG PRKX

Compounds Affecting Opioid Signalling

#	Compound	Targets Hit	Studies
1	Papaverine	—	299
2	sp600125	—	117
3	hydroxyfasudil [Supplementary Concept]	—	11
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	alsterpaullone	—	12
6	vinpocetine	—	299
7	Aurintricarboxylic Acid	—	184
8	Fluspirilene	—	74
9	Disulfiram	—	297
10	Calcimycin	—	216
11	Sorafenib	—	300
12	streptonigrin	—	299
13	Codeine	—	295
14	hydrocodone	—	294
15	Clofarabine	—	298
16	Ethidium	—	300
17	trequinsin hydrochloride	—	1
18	chrysin	—	300
19	Quercetin	—	300
20	Cladribine	—	297
21	Daunorubicin	—	298
22	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
23	Thyroxine	—	994
24	Crizotinib	—	298
25	Thyroxine	—	300
26	Troglitazone	—	299
27	tyrphostin ag 1478	—	4
28	kenpaullone	—	8
29	Clotrimazole	—	296
30	fisetin	—	78
31	Enoximone	—	300
32	8-Bromo Cyclic Adenosine Monophosphate	—	101
33	Anthralin	—	299
34	Hexachlorophene	—	300
35	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
36	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
37	Tetracycline	—	300
38	Cefixime	—	300
39	Sphingosine	—	300
40	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
41	Axitinib	—	298
42	Morphine	—	294
43	Naloxone	—	299
44	Fentanyl	—	300
45	Nalbuphine	—	298
46	Butorphanol	—	299
47	Oxycodone	—	298
48	Levorphanol	—	297
49	Nalorphine	—	300
50	Pentazocine	—	299

About the Opioid Signalling Pathway

The Opioid Signalling pathway is catalogued in Reactome (ID: R-HSA-111885) and involves 26 genes. In the BiohacksAI corpus, 199 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, CAMK2B, CAMK2D, CAMKK1, CAMKK2.