What compounds affect the MAPK1 (ERK2) activation pathway?

43 compounds in the BiohacksAI corpus have documented interactions with genes in the MAPK1 (ERK2) activation pathway (Reactome ID: R-HSA-112411). These compounds target 5 genes within this pathway.

What genes are in the MAPK1 (ERK2) activation pathway?

The MAPK1 (ERK2) activation pathway involves 5 genes. Key genes include: IL6, JAK2, MAP2K2, MAPK1, TYK2.

MAPK1 (ERK2) activation

REACTOME PATHWAY

Reactome: R-HSA-1124115 genes43 compounds

The MAPK1 (ERK2) activation pathway (Reactome ID: R-HSA-112411) involves 5 genes and is affected by 43 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

IL6 JAK2 MAP2K2 MAPK1 TYK2

Compounds Affecting MAPK1 (ERK2) activation

#	Compound	Targets Hit	Studies
1	pd98059	—	7
2	sp600125	—	117
3	trametinib	—	296
4	Dasatinib	—	299
5	Axitinib	—	298
6	plumbagin [Supplementary Concept]	—	300
7	tyrphostin ag 1478	—	4
8	alsterpaullone	—	12
9	kenpaullone	—	8
10	Clotrimazole	—	296
11	fisetin	—	78
12	Progesterone	—	299
13	2-Chloroadenosine 2-Chloroadenosine.	—	300
14	Benzalkonium Compounds	—	299
15	Calcimycin	—	216
16	daph	—	2
17	Diphenhydramine	—	14
18	ha1004	—	4
19	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
20	Lithocholic Acid	—	300
21	Loratadine	—	296
22	Sorafenib	—	300
23	trequinsin hydrochloride	—	1
24	withaferin	—	300
25	Azauridine	—	300
26	Cladribine	—	297
27	Methylene Blue	—	200
28	2-Methoxyestradiol	—	300
29	Astemizole Antihistamine drug now withdrawn from	—	280
30	Azathioprine	—	300
31	Calcitriol	—	300
32	Camptothecin	—	300
33	Cytarabine	—	297
34	dihydrorotenone	—	13
35	Podophyllotoxin	—	14
36	streptonigrin	—	299
37	Trifluridine	—	295
38	Tripterygium	—	300
39	Crizotinib	—	298
40	Methotrexate	—	289
41	pictilisib	—	25
42	Vemurafenib	—	298
43	Prednisolone	—	1,000

About the MAPK1 (ERK2) activation Pathway

The MAPK1 (ERK2) activation pathway is catalogued in Reactome (ID: R-HSA-112411) and involves 5 genes. In the BiohacksAI corpus, 43 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IL6, JAK2, MAP2K2, MAPK1, TYK2.