Regulation of gene expression by Hypoxia-inducible Factor

Q: What compounds affect the Regulation of gene expression by Hypoxia-inducible Factor pathway?

92 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of gene expression by Hypoxia-inducible Factor pathway (Reactome ID: R-HSA-1234158). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-12341586 genes92 compounds

The Regulation of gene expression by Hypoxia-inducible Factor pathway (Reactome ID: R-HSA-1234158) involves 6 genes and is affected by 92 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARNT CA9 CREBBP EP300 EPAS1 HIF1A

Compounds Affecting Regulation of gene expression by Hypoxia-inducible Factor

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Emetine	—	298
3	cycloheximide	—	300
4	Topotecan	—	300
5	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
6	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
7	chrysin	—	300
8	egcg	—	300
9	Quercetin	—	300
10	Resveratrol	—	298
11	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
12	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
13	Digoxin	—	299
14	gedunin	—	54
15	Oxytetracycline	—	300
16	Tubercidin	—	300
17	Gliotoxin	—	300
18	Harmaline	—	300
19	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
20	Loratadine	—	296
21	oxatomide [Supplementary Concept] structure;	—	128
22	triolimus [Supplementary Concept]	—	33
23	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
24	Hydrocortisone	—	299
25	Kaempferols	—	300
26	2-Chloroadenosine 2-Chloroadenosine.	—	300
27	ag490	—	14
28	Beclomethasone	—	300
29	Camptothecin	—	300
30	celastrol	—	300
31	Clotrimazole	—	296
32	cycloserine	—	298
33	Dequalinium	—	136
34	Desoximetasone	—	86
35	Epinephrine	—	299
36	Ethoxyquin Antioxidant; also	—	180
37	Fusaric Acid	—	300
38	Hesperidin	—	300
39	Hydrocortisone	—	298
40	Mometasone Furoate	—	292
41	Niclosamide	—	299
42	Nisoldipine	—	297
43	Phenoxybenzamine	—	21
44	sp600125	—	117
45	tyrphostin 9	—	2
46	Sulfanilamide	—	300
47	Celecoxib	—	295
48	Zonisamide	—	297
49	Mafenide	—	169
50	Phenol	—	297

About the Regulation of gene expression by Hypoxia-inducible Factor Pathway

The Regulation of gene expression by Hypoxia-inducible Factor pathway is catalogued in Reactome (ID: R-HSA-1234158) and involves 6 genes. In the BiohacksAI corpus, 92 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARNT, CA9, CREBBP, EP300, EPAS1.