Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

Q: What compounds affect the Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants pathway?

40 compounds in the BiohacksAI corpus have documented interactions with genes in the Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants pathway (Reactome ID: R-HSA-1236382). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-12363825 genes40 compounds

The Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants pathway (Reactome ID: R-HSA-1236382) involves 5 genes and is affected by 40 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC37 EGFR GRB2 HSP90AA1 PIK3R1

Compounds Affecting Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

#	Compound	Targets Hit	Studies
1	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
2	celastrol	—	300
3	Quercetin	—	300
4	ag490	—	14
5	Wortmannin	—	300
6	triolimus [Supplementary Concept]	—	33
7	monorden	—	8
8	gedunin	—	54
9	Novobiocin	—	300
10	caffeic acid	—	300
11	Masoprocol	—	300
12	Tetracycline	—	300
13	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	2-Chloroadenosine 2-Chloroadenosine.	—	300
16	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
17	Calcimycin	—	216
18	Calcitriol	—	300
19	Ciclopirox	—	88
20	Clotrimazole	—	296
21	cycloheximide	—	300
22	deguelin [Supplementary Concept]	—	151
23	Disulfiram	—	297
24	Hexachlorophene	—	300
25	Idarubicin	—	299
26	Indazoles	—	300
27	Miconazole	—	298
28	piceatannol	—	300
29	Nitroprusside	—	299
30	specioside	—	6
31	pictilisib	—	25
32	ly294002	—	11
33	alpelisib	—	227
34	Sirolimus	—	300
35	torin 1	—	10
36	Dasatinib	—	299
37	Afatinib	—	297
38	tyrphostin ag 1478	—	4
39	tyrphostin 1	—	1
40	Dactinomycin	—	297

About the Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Pathway

The Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants pathway is catalogued in Reactome (ID: R-HSA-1236382) and involves 5 genes. In the BiohacksAI corpus, 40 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC37, EGFR, GRB2, HSP90AA1, PIK3R1.