Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

Q: What compounds affect the Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway (Reactome ID: R-HSA-1474151). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-14741513 genes42 compounds

The Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway (Reactome ID: R-HSA-1474151) involves 3 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

DHFR HSP90AA1 NOS3

Compounds Affecting Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

#	Compound	Targets Hit	Studies
1	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
2	triolimus [Supplementary Concept]	—	33
3	monorden	—	8
4	gedunin	—	54
5	celastrol	—	300
6	Novobiocin	—	300
7	caffeic acid	—	300
8	Masoprocol	—	300
9	Tetracycline	—	300
10	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	Quercetin	—	300
13	2-Chloroadenosine 2-Chloroadenosine.	—	300
14	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
15	ag490	—	14
16	Calcimycin	—	216
17	Calcitriol	—	300
18	Ciclopirox	—	88
19	Clotrimazole	—	296
20	cycloheximide	—	300
21	deguelin [Supplementary Concept]	—	151
22	Disulfiram	—	297
23	Hexachlorophene	—	300
24	Idarubicin	—	299
25	Indazoles	—	300
26	Miconazole	—	298
27	piceatannol	—	300
28	Nitroprusside	—	299
29	specioside	—	6
30	Wortmannin	—	300
31	Methotrexate	—	289
32	Pemetrexed	—	299
33	egcg	—	300
34	Folic Acid	—	296
35	Leucovorin	—	297
36	Sulfadiazine	—	298
37	NG-Nitroarginine Methyl Ester	—	238
38	Nitroarginine	—	300
39	Catechin	—	300
40	Arginine	—	300
41	Arginine	—	300
42	sesamol	—	293

About the Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Pathway

The Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway is catalogued in Reactome (ID: R-HSA-1474151) and involves 3 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DHFR, HSP90AA1, NOS3.