What compounds affect the Glycerophospholipid biosynthesis pathway?

93 compounds in the BiohacksAI corpus have documented interactions with genes in the Glycerophospholipid biosynthesis pathway (Reactome ID: R-HSA-1483206). These compounds target 10 genes within this pathway.

What genes are in the Glycerophospholipid biosynthesis pathway?

The Glycerophospholipid biosynthesis pathway involves 10 genes. Key genes include: ACHE, BCHE, CSNK2A1, CSNK2A2, CSNK2B, MGLL, PHOSPHO1, PLA2G1B, PLA2G3, PLD2.

Glycerophospholipid biosynthesis

REACTOME PATHWAY

Reactome: R-HSA-148320610 genes93 compounds

The Glycerophospholipid biosynthesis pathway (Reactome ID: R-HSA-1483206) involves 10 genes and is affected by 93 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ACHE BCHE CSNK2A1 CSNK2A2 CSNK2B MGLL PHOSPHO1 PLA2G1B PLA2G3 PLD2

Compounds Affecting Glycerophospholipid biosynthesis

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	fisetin	—	78
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	Kaempferols	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	chrysin	—	300
9	Vanillic Acid	—	300
10	ly294002	—	11
11	Physostigmine	—	300
12	Physostigmine	—	299
13	Berberine	—	300
14	ethopropazine	—	17
15	Hexachlorophene	—	300
16	Disulfiram	—	297
17	Reserpine	—	297
18	bis(12)-hupyridone [Supplementary Concept]	—	300
19	Methylene Blue	—	200
20	Ranitidine	—	299
21	Chlorhexidine	—	299
22	Ethidium	—	300
23	Metergoline	—	144
24	Nicergoline	—	300
25	Progesterone	—	299
26	Phenylglyoxal	—	300
27	Procainamide	—	297
28	Tilorone	—	300
29	Acetaldehyde	—	300
30	Carbaryl	—	300
31	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
32	Dihydroergotamine	—	299
33	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
34	Methysergide	—	300
35	Promethazine	—	121
36	Thioridazine	—	35
37	Caffeine	—	299
38	Amisulpride	—	298
39	Astemizole Antihistamine drug now withdrawn from	—	280
40	Hyoscyamine	—	296
41	Dinitrochlorobenzene	—	300
42	Edaravone	—	298
43	Methoxsalen	—	300
44	pirenperone	—	22
45	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
46	Vecuronium Bromide Monoquaternary homolog of PANCURONIUM.	—	298
47	caffeic acid	—	300
48	Fluoxetine	—	1,000
49	Rutin	—	300
50	Aripiprazole	—	298

About the Glycerophospholipid biosynthesis Pathway

The Glycerophospholipid biosynthesis pathway is catalogued in Reactome (ID: R-HSA-1483206) and involves 10 genes. In the BiohacksAI corpus, 93 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ACHE, BCHE, CSNK2A1, CSNK2A2, CSNK2B.