What compounds affect the Cell-Cell communication pathway?

154 compounds in the BiohacksAI corpus have documented interactions with genes in the Cell-Cell communication pathway (Reactome ID: R-HSA-1500931). These compounds target 66 genes within this pathway.

What genes are in the Cell-Cell communication pathway?

The Cell-Cell communication pathway involves 66 genes. Key genes include: ADRM1, AGO2, CASK, CD47, CSNK2A1, CSNK2A2, CSNK2A3, CSNK2B, CTBP1, CTSL.

Cell-Cell communication

REACTOME PATHWAY

Reactome: R-HSA-150093166 genes154 compounds

The Cell-Cell communication pathway (Reactome ID: R-HSA-1500931) involves 66 genes and is affected by 154 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 CASK CD47 CSNK2A1 CSNK2A2 CSNK2A3 CSNK2B CTBP1 CTSL EED EZH2 FURIN FYN GANAB GRB2 HDAC1 HDAC2 KDM1A KMT5A MAPK1 MAPK3 MDM2 MPHOSPH8 MYC PIK3CB PIK3R1 PIK3R2 PKM PSMA1+36 more

Compounds Affecting Cell-Cell communication

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	fisetin	—	78
7	Sorafenib	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	ly294002	—	11
10	pictilisib	—	25
11	kenpaullone	—	8
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	chrysin	—	300
14	Crizotinib	—	298
15	alsterpaullone	—	12
16	Kaempferols	—	300
17	Vanillic Acid	—	300
18	Sirolimus	—	300
19	Niclosamide	—	299
20	Ursolic Acid	—	300
21	sp600125	—	117
22	Vorinostat	—	299
23	Aurintricarboxylic Acid	—	184
24	Idarubicin	—	299
25	pd98059	—	7
26	tyrphostin ag 1478	—	4
27	Dasatinib	—	299
28	Resveratrol	—	298
29	Calcimycin	—	216
30	cycloheximide	—	300
31	Astemizole Antihistamine drug now withdrawn from	—	280
32	Fluspirilene	—	74
33	tyrphostin 9	—	2
34	Methotrexate	—	289
35	Thioridazine	—	35
36	daph	—	2
37	Disulfiram	—	297
38	trequinsin hydrochloride	—	1
39	plumbagin [Supplementary Concept]	—	300
40	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
41	trametinib	—	296
42	withaferin	—	300
43	Axitinib	—	298
44	egcg	—	300
45	Genistein	—	300
46	Suramin	—	300
47	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
48	scriptaid	—	53
49	Valproic Acid	—	296
50	Butyric Acid	—	300

About the Cell-Cell communication Pathway

The Cell-Cell communication pathway is catalogued in Reactome (ID: R-HSA-1500931) and involves 66 genes. In the BiohacksAI corpus, 154 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, CASK, CD47, CSNK2A1.