What compounds affect the G0 and Early G1 pathway?

47 compounds in the BiohacksAI corpus have documented interactions with genes in the G0 and Early G1 pathway (Reactome ID: R-HSA-1538133). These compounds target 9 genes within this pathway.

What genes are in the G0 and Early G1 pathway?

The G0 and Early G1 pathway involves 9 genes. Key genes include: CCNA1, CCNE2, CDC25A, CDK1, CDK2, HDAC1, MYC, PCNA, TOP2A.

G0 and Early G1

REACTOME PATHWAY

Reactome: R-HSA-15381339 genes47 compounds

The G0 and Early G1 pathway (Reactome ID: R-HSA-1538133) involves 9 genes and is affected by 47 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNA1 CCNE2 CDC25A CDK1 CDK2 HDAC1 MYC PCNA TOP2A

Compounds Affecting G0 and Early G1

#	Compound	Targets Hit	Studies
1	kenpaullone	—	8
2	alsterpaullone	—	12
3	sp600125	—	117
4	fisetin	—	78
5	Quercetin	—	300
6	Daunorubicin	—	298
7	indirubin	—	300
8	Clofibrate	—	299
9	Fenofibrate	—	297
10	Sertraline	—	1,000
11	Cinnarizine	—	299
12	Clotrimazole	—	296
13	Rotenone	—	300
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	chrysin	—	300
16	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
17	Sorafenib	—	300
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	Genistein	—	300
20	Ethidium	—	300
21	Teniposide	—	299
22	Topotecan	—	300
23	Ciprofloxacin	—	1,000
24	Aclarubicin	—	300
25	Dexrazoxane	—	298
26	Digitoxin	—	300
27	Epirubicin	—	300
28	Idarubicin	—	299
29	Vorinostat	—	299
30	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
31	scriptaid	—	53
32	Valproic Acid	—	296
33	pictilisib	—	25
34	Butyric Acid	—	300
35	Ursolic Acid	—	300
36	Celecoxib	—	295
37	Bortezomib	—	300
38	Camptothecin	—	300
39	Aurintricarboxylic Acid	—	184
40	Methylergonovine	—	14
41	Adenosine Triphosphate	—	300
42	plumbagin [Supplementary Concept]	—	300
43	Vitamin K 3	—	300
44	Danazol	—	298
45	Methysergide	—	300
46	Oleanolic Acid	—	300
47	Triiodothyronine	—	300

About the G0 and Early G1 Pathway

The G0 and Early G1 pathway is catalogued in Reactome (ID: R-HSA-1538133) and involves 9 genes. In the BiohacksAI corpus, 47 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNA1, CCNE2, CDC25A, CDK1, CDK2.