What compounds affect the mTORC1-mediated signalling pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the mTORC1-mediated signalling pathway (Reactome ID: R-HSA-166208). These compounds target 7 genes within this pathway.

What genes are in the mTORC1-mediated signalling pathway?

The mTORC1-mediated signalling pathway involves 7 genes. Key genes include: EIF4G1, FKBP1A, MLST8, MTOR, RPS6KB1, RPTOR, YWHAB.

mTORC1-mediated signalling

REACTOME PATHWAY

Reactome: R-HSA-1662087 genes42 compounds

The mTORC1-mediated signalling pathway (Reactome ID: R-HSA-166208) involves 7 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EIF4G1 FKBP1A MLST8 MTOR RPS6KB1 RPTOR YWHAB

Compounds Affecting mTORC1-mediated signalling

#	Compound	Targets Hit	Studies
1	Sirolimus	—	300
2	Everolimus	—	297
3	torin 1	—	10
4	Ku 0063794 [Supplementary Concept]	—	7
5	pictilisib	—	25
6	ly294002	—	11
7	Rotenone	—	300
8	Thapsigargin	—	300
9	Wortmannin	—	300
10	alpelisib	—	227
11	amn082	—	29
12	Calcimycin	—	216
13	Idarubicin	—	299
14	Idazoxan	—	300
15	Niclosamide	—	299
16	triolimus [Supplementary Concept]	—	33
17	tyrphostin 9	—	2
18	egcg	—	300
19	Ursolic Acid	—	300
20	Camptothecin	—	300
21	Dequalinium	—	136
22	Disulfiram	—	297
23	Emetine	—	298
24	Epinephrine	—	299
25	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
26	Maprotiline	—	299
27	Perphenazine	—	297
28	DEAD-box RNA Helicases	—	169
29	Thioctic Acid	—	298
30	Hexachlorophene	—	300
31	Thioctic Acid	—	300
32	Azauridine	—	300
33	Levetiracetam	—	296
34	Oxytetracycline	—	300
35	hydroxyfasudil [Supplementary Concept]	—	11
36	alsterpaullone	—	12
37	Crizotinib	—	298
38	Sorafenib	—	300
39	sp600125	—	117
40	cycloheximide	—	300
41	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
42	Quercetin	—	300

About the mTORC1-mediated signalling Pathway

The mTORC1-mediated signalling pathway is catalogued in Reactome (ID: R-HSA-166208) and involves 7 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EIF4G1, FKBP1A, MLST8, MTOR, RPS6KB1.