What compounds affect the Estrogen biosynthesis pathway?

103 compounds in the BiohacksAI corpus have documented interactions with genes in the Estrogen biosynthesis pathway (Reactome ID: R-HSA-193144). These compounds target 2 genes within this pathway.

What genes are in the Estrogen biosynthesis pathway?

The Estrogen biosynthesis pathway involves 2 genes. Key genes include: CYP19A1, HSD17B1.

Estrogen biosynthesis

REACTOME PATHWAY

Reactome: R-HSA-1931442 genes103 compounds

The Estrogen biosynthesis pathway (Reactome ID: R-HSA-193144) involves 2 genes and is affected by 103 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP19A1 HSD17B1

Compounds Affecting Estrogen biosynthesis

#	Compound	Targets Hit	Studies
1	Kaempferols	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Kaempferols	—	300
4	Estrone	—	300
5	Masoprocol	—	300
6	Letrozole	—	298
7	Fadrozole	—	300
8	Anastrozole	—	298
9	chrysin	—	300
10	Androstenedione	—	300
11	Clotrimazole	—	296
12	Methylene Blue	—	200
13	Testosterone	—	299
14	Bortezomib	—	300
15	cycloheximide	—	300
16	Ethidium	—	300
17	Fulvestrant	—	295
18	Lovastatin	—	300
19	Miconazole	—	298
20	Reserpine	—	297
21	Spironolactone	—	298
22	Vitamin	—	295
23	Dactinomycin	—	297
24	Dihydrotestosterone	—	300
25	Disulfiram	—	297
26	Hexachlorophene	—	300
27	mg624	—	3
28	Ouabain	—	300
29	Rotenone	—	300
30	stx64	—	2
31	Acetaldehyde	—	300
32	Amoxapine	—	259
33	Astemizole Antihistamine drug now withdrawn from	—	280
34	Azacitidine	—	298
35	Azacitidine	—	300
36	Celecoxib	—	295
37	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
38	Chlorhexidine	—	299
39	Daunorubicin	—	298
40	Digoxin	—	299
41	Dinitrochlorobenzene	—	300
42	Emetine	—	298
43	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
44	Flutamide	—	298
45	Nisoldipine	—	297
46	Nitrofurantoin	—	297
47	ns398	—	116
48	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
49	Toxaphene	—	299
50	Trabectedin	—	297

About the Estrogen biosynthesis Pathway

The Estrogen biosynthesis pathway is catalogued in Reactome (ID: R-HSA-193144) and involves 2 genes. In the BiohacksAI corpus, 103 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP19A1, HSD17B1.