What compounds affect the p75 NTR receptor-mediated signalling pathway?

66 compounds in the BiohacksAI corpus have documented interactions with genes in the p75 NTR receptor-mediated signalling pathway (Reactome ID: R-HSA-193704). These compounds target 20 genes within this pathway.

What genes are in the p75 NTR receptor-mediated signalling pathway?

The p75 NTR receptor-mediated signalling pathway involves 20 genes. Key genes include: ADAM17, APH1A, APH1B, BAD, BCL2L11, CASP2, HDAC1, HDAC2, HDAC3, IKBKB.

p75 NTR receptor-mediated signalling

REACTOME PATHWAY

Reactome: R-HSA-19370420 genes66 compounds

The p75 NTR receptor-mediated signalling pathway (Reactome ID: R-HSA-193704) involves 20 genes and is affected by 66 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM17 APH1A APH1B BAD BCL2L11 CASP2 HDAC1 HDAC2 HDAC3 IKBKB IRAK1 MAPK8 NCSTN NFKB1 NFKBIA PSEN1 PSEN2 PSENEN RELA RIPK2

Compounds Affecting p75 NTR receptor-mediated signalling

#	Compound	Targets Hit	Studies
1	Dihydroergocristine	—	187
2	Bortezomib	—	300
3	Ursolic Acid	—	300
4	pictilisib	—	25
5	Kaempferols	—	300
6	chicoric acid	—	117
7	Vorinostat	—	299
8	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
9	scriptaid	—	53
10	Valproic Acid	—	296
11	Butyric Acid	—	300
12	Celecoxib	—	295
13	Daunorubicin	—	298
14	Camptothecin	—	300
15	Anisomycin	—	247
16	Axitinib	—	298
17	Crizotinib	—	298
18	Quercetin	—	300
19	Resveratrol	—	298
20	Podophyllotoxin	—	14
21	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
22	egcg	—	300
23	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
24	Rutin	—	300
25	Withania	—	500
26	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
27	tamarixetin	—	26
28	Trifluridine	—	295
29	withaferin	—	300
30	Sorafenib	—	300
31	Afatinib	—	297
32	sp600125	—	117
33	alsterpaullone	—	12
34	Hydrocortisone	—	299
35	Cerulenin	—	300
36	Chlorpropamide	—	300
37	daph	—	2
38	Disulfiram	—	297
39	Hexachlorophene	—	300
40	Hydrocortisone	—	298
41	Lovastatin	—	300
42	ly294002	—	11
43	Promethazine	—	121
44	protriptyline	—	296
45	streptonigrin	—	299
46	Sulfaphenazole	—	300
47	Triamcinolone	—	300
48	tyrphostin 1	—	1
49	tyrphostin ag 1478	—	4
50	Voriconazole	—	299

About the p75 NTR receptor-mediated signalling Pathway

The p75 NTR receptor-mediated signalling pathway is catalogued in Reactome (ID: R-HSA-193704) and involves 20 genes. In the BiohacksAI corpus, 66 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM17, APH1A, APH1B, BAD, BCL2L11.