What compounds affect the ERK/MAPK targets pathway?

39 compounds in the BiohacksAI corpus have documented interactions with genes in the ERK/MAPK targets pathway (Reactome ID: R-HSA-198753). These compounds target 11 genes within this pathway.

What genes are in the ERK/MAPK targets pathway?

The ERK/MAPK targets pathway involves 11 genes. Key genes include: DUSP3, MAPK1, MAPK11, MAPK14, MAPK3, MAPK7, PPP2CA, RPS6KA1, RPS6KA2, RPS6KA3.

ERK/MAPK targets

REACTOME PATHWAY

Reactome: R-HSA-19875311 genes39 compounds

The ERK/MAPK targets pathway (Reactome ID: R-HSA-198753) involves 11 genes and is affected by 39 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

DUSP3 MAPK1 MAPK11 MAPK14 MAPK3 MAPK7 PPP2CA RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5

Compounds Affecting ERK/MAPK targets

#	Compound	Targets Hit	Studies
1	fisetin	—	78
2	Sorafenib	—	300
3	sp600125	—	117
4	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
5	withaferin	—	300
6	hydroxyfasudil [Supplementary Concept]	—	11
7	plumbagin [Supplementary Concept]	—	300
8	pd98059	—	7
9	tyrphostin ag 1478	—	4
10	alsterpaullone	—	12
11	kenpaullone	—	8
12	trametinib	—	296
13	Dasatinib	—	299
14	Afatinib	—	297
15	Anisomycin	—	247
16	Clotrimazole	—	296
17	Progesterone	—	299
18	2-Chloroadenosine 2-Chloroadenosine.	—	300
19	Benzalkonium Compounds	—	299
20	Calcimycin	—	216
21	daph	—	2
22	Diphenhydramine	—	14
23	ha1004	—	4
24	Lithocholic Acid	—	300
25	Loratadine	—	296
26	trequinsin hydrochloride	—	1
27	egcg	—	300
28	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
29	Quercetin	—	300
30	Celecoxib	—	295
31	Kaempferols	—	300
32	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
33	pictilisib	—	25
34	DEAD-box RNA Helicases	—	169
35	Thioctic Acid	—	298
36	Oleanolic Acid	—	300
37	Thioctic Acid	—	300
38	Crizotinib	—	298
39	Okadaic Acid	—	300

About the ERK/MAPK targets Pathway

The ERK/MAPK targets pathway is catalogued in Reactome (ID: R-HSA-198753) and involves 11 genes. In the BiohacksAI corpus, 39 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DUSP3, MAPK1, MAPK11, MAPK14, MAPK3.