What compounds affect the TCR signaling pathway?

83 compounds in the BiohacksAI corpus have documented interactions with genes in the TCR signaling pathway (Reactome ID: R-HSA-202403). These compounds target 51 genes within this pathway.

What genes are in the TCR signaling pathway?

The TCR signaling pathway involves 51 genes. Key genes include: ADRM1, CHUK, CSK, CUL1, IKBKB, ITK, LAT, LCK, MAP3K7, NFKB1.

TCR signaling

REACTOME PATHWAY

Reactome: R-HSA-20240351 genes83 compounds

The TCR signaling pathway (Reactome ID: R-HSA-202403) involves 51 genes and is affected by 83 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CHUK CSK CUL1 IKBKB ITK LAT LCK MAP3K7 NFKB1 NFKBIA PDPK1 PIK3CB PIK3R1 PIK3R2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1+21 more

Compounds Affecting TCR signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Crizotinib	—	298
4	Quercetin	—	300
5	Resveratrol	—	298
6	ly294002	—	11
7	chicoric acid	—	117
8	Sorafenib	—	300
9	Axitinib	—	298
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	Dasatinib	—	299
13	sp600125	—	117
14	Swainsonine	—	300
15	pictilisib	—	25
16	Sirolimus	—	300
17	Podophyllotoxin	—	14
18	egcg	—	300
19	Kaempferols	—	300
20	Rutin	—	300
21	Withania	—	500
22	Disulfiram	—	297
23	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
24	tamarixetin	—	26
25	Trifluridine	—	295
26	tyrphostin ag 1478	—	4
27	withaferin	—	300
28	Oleanolic Acid	—	300
29	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
30	kenpaullone	—	8
31	Afatinib	—	297
32	Wortmannin	—	300
33	alpelisib	—	227
34	alsterpaullone	—	12
35	Hydrocortisone	—	299
36	Cerulenin	—	300
37	Chlorpropamide	—	300
38	daph	—	2
39	Hexachlorophene	—	300
40	Hydrocortisone	—	298
41	Lovastatin	—	300
42	Promethazine	—	121
43	protriptyline	—	296
44	streptonigrin	—	299
45	Sulfaphenazole	—	300
46	Triamcinolone	—	300
47	tyrphostin 1	—	1
48	Voriconazole	—	299
49	Cathelicidins Antimicrobial cationic peptides with	—	300
50	plumbagin [Supplementary Concept]	—	300

About the TCR signaling Pathway

The TCR signaling pathway is catalogued in Reactome (ID: R-HSA-202403) and involves 51 genes. In the BiohacksAI corpus, 83 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CHUK, CSK, CUL1, IKBKB.