What compounds affect the Downstream TCR signaling pathway?

82 compounds in the BiohacksAI corpus have documented interactions with genes in the Downstream TCR signaling pathway (Reactome ID: R-HSA-202424). These compounds target 46 genes within this pathway.

What genes are in the Downstream TCR signaling pathway?

The Downstream TCR signaling pathway involves 46 genes. Key genes include: ADRM1, CHUK, CUL1, IKBKB, LCK, MAP3K7, NFKB1, NFKBIA, PDPK1, PIK3CB.

Downstream TCR signaling

REACTOME PATHWAY

Reactome: R-HSA-20242446 genes82 compounds

The Downstream TCR signaling pathway (Reactome ID: R-HSA-202424) involves 46 genes and is affected by 82 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CHUK CUL1 IKBKB LCK MAP3K7 NFKB1 NFKBIA PDPK1 PIK3CB PIK3R1 PIK3R2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4+16 more

Compounds Affecting Downstream TCR signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Resveratrol	—	298
5	ly294002	—	11
6	chicoric acid	—	117
7	Crizotinib	—	298
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Sorafenib	—	300
11	sp600125	—	117
12	pictilisib	—	25
13	Sirolimus	—	300
14	Podophyllotoxin	—	14
15	egcg	—	300
16	Kaempferols	—	300
17	Rutin	—	300
18	Withania	—	500
19	Disulfiram	—	297
20	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
21	tamarixetin	—	26
22	Trifluridine	—	295
23	tyrphostin ag 1478	—	4
24	withaferin	—	300
25	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
26	Dasatinib	—	299
27	kenpaullone	—	8
28	Afatinib	—	297
29	Axitinib	—	298
30	Wortmannin	—	300
31	alpelisib	—	227
32	alsterpaullone	—	12
33	Hydrocortisone	—	299
34	Cerulenin	—	300
35	Chlorpropamide	—	300
36	daph	—	2
37	Hexachlorophene	—	300
38	Hydrocortisone	—	298
39	Lovastatin	—	300
40	Promethazine	—	121
41	protriptyline	—	296
42	streptonigrin	—	299
43	Sulfaphenazole	—	300
44	Triamcinolone	—	300
45	tyrphostin 1	—	1
46	Voriconazole	—	299
47	Cathelicidins Antimicrobial cationic peptides with	—	300
48	plumbagin [Supplementary Concept]	—	300
49	Ursolic Acid	—	300
50	Oleanolic Acid	—	300

About the Downstream TCR signaling Pathway

The Downstream TCR signaling pathway is catalogued in Reactome (ID: R-HSA-202424) and involves 46 genes. In the BiohacksAI corpus, 82 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CHUK, CUL1, IKBKB, LCK.