What compounds affect the Miscellaneous substrates pathway?

325 compounds in the BiohacksAI corpus have documented interactions with genes in the Miscellaneous substrates pathway (Reactome ID: R-HSA-211958). These compounds target 2 genes within this pathway.

What genes are in the Miscellaneous substrates pathway?

The Miscellaneous substrates pathway involves 2 genes. Key genes include: CYP2D6, CYP3A43.

Miscellaneous substrates

REACTOME PATHWAY

Reactome: R-HSA-2119582 genes325 compounds

The Miscellaneous substrates pathway (Reactome ID: R-HSA-211958) involves 2 genes and is affected by 325 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP2D6 CYP3A43

Compounds Affecting Miscellaneous substrates

#	Compound	Targets Hit	Studies
1	Ritonavir	—	298
2	Quinidine	—	298
3	Yohimbine	—	299
4	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
5	Chlorhexidine	—	299
6	Cyproheptadine	—	299
7	Maprotiline	—	299
8	Methoxsalen	—	300
9	Oxymetazoline	—	298
10	Nortriptyline	—	295
11	Kaempferols	—	300
12	Amoxapine	—	259
13	Astemizole Antihistamine drug now withdrawn from	—	280
14	Celecoxib	—	295
15	Danazol	—	298
16	Fluspirilene	—	74
17	Loratadine	—	296
18	Perphenazine	—	297
19	Piribedil	—	300
20	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
21	Timolol	—	298
22	Tolazamide	—	169
23	Buspirone	—	299
24	Clotrimazole	—	296
25	Domperidone	—	299
26	doxylamine succinate	—	35
27	Ethoxyquin Antioxidant; also	—	180
28	Phentolamine	—	300
29	Piperonyl Butoxide	—	300
30	Methylene Blue	—	200
31	Progesterone	—	299
32	Cimetidine	—	299
33	clofilium tosylate	—	4
34	Clonidine	—	299
35	Physostigmine	—	300
36	Ethidium	—	300
37	lidoflazine	—	278
38	Melphalan	—	300
39	Vitamin K 3	—	300
40	Metoclopramide	—	297
41	Miconazole	—	298
42	Niacin	—	295
43	oxatomide [Supplementary Concept] structure;	—	128
44	Phenelzine	—	2
45	Physostigmine	—	299
46	Propantheline	—	73
47	Reserpine	—	297
48	Sulindac	—	297
49	Tetracycline	—	52
50	Vincamine	—	300

About the Miscellaneous substrates Pathway

The Miscellaneous substrates pathway is catalogued in Reactome (ID: R-HSA-211958) and involves 2 genes. In the BiohacksAI corpus, 325 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP2D6, CYP3A43.