SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Q: What compounds affect the SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway?

95 compounds in the BiohacksAI corpus have documented interactions with genes in the SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway (Reactome ID: R-HSA-2173796). These compounds target 14 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-217379614 genes95 compounds

The SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway (Reactome ID: R-HSA-2173796) involves 14 genes and is affected by 95 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNC CCNT2 CDK8 CDK9 EP300 FURIN HDAC1 MAPK1 MAPK3 MEN1 MYC SERPINE1 SMAD2 SMAD3

Compounds Affecting SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

#	Compound	Targets Hit	Studies
1	alsterpaullone	—	12
2	kenpaullone	—	8
3	egcg	—	300
4	Sorafenib	—	300
5	Danazol	—	298
6	Loratadine	—	296
7	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
8	Bortezomib	—	300
9	Celecoxib	—	295
10	Daunorubicin	—	298
11	trequinsin hydrochloride	—	1
12	plumbagin [Supplementary Concept]	—	300
13	Calcimycin	—	216
14	cycloheximide	—	300
15	Azacitidine	—	298
16	Azacitidine	—	300
17	Disulfiram	—	297
18	Nisoldipine	—	297
19	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
20	Kaempferols	—	300
21	Quercetin	—	300
22	Colchicine	—	300
23	Dactinomycin	—	297
24	Dasatinib	—	299
25	Dinitrochlorobenzene	—	300
26	Ethidium	—	300
27	Flutamide	—	298
28	Oxyphenbutazone	—	300
29	Podophyllotoxin	—	14
30	vinblastine sulfate	—	81
31	Vincristine	—	299
32	chrysin	—	300
33	Fluoxetine	—	1,000
34	Astemizole Antihistamine drug now withdrawn from	—	280
35	Ciclopirox	—	88
36	Cladribine	—	297
37	Domperidone	—	299
38	Emetine	—	298
39	Equilin	—	216
40	Ethinyl Estradiol	—	300
41	Ezetimibe	—	296
42	Hexachlorophene	—	300
43	Idazoxan	—	300
44	Lynestrenol	—	299
45	Nocodazole Nocodazole is	—	215
46	Masoprocol	—	300
47	o-Phthalaldehyde	—	300
48	Perphenazine	—	297
49	pivampicillin	—	275
50	Promethazine	—	121

About the SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Pathway

The SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway is catalogued in Reactome (ID: R-HSA-2173796) and involves 14 genes. In the BiohacksAI corpus, 95 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNC, CCNT2, CDK8, CDK9, EP300.