What genes are in the Metabolism of ingested SeMet, Sec, MeSec into H2Se pathway?

The Metabolism of ingested SeMet, Sec, MeSec into H2Se pathway involves 7 genes. Key genes include: AHCY, CBS, CTH, GNMT, HNMT, LOC102724560, NNMT.

Metabolism of ingested SeMet, Sec, MeSec into H2Se

Q: What compounds affect the Metabolism of ingested SeMet, Sec, MeSec into H2Se pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of ingested SeMet, Sec, MeSec into H2Se pathway (Reactome ID: R-HSA-2408508). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-24085087 genes42 compounds

The Metabolism of ingested SeMet, Sec, MeSec into H2Se pathway (Reactome ID: R-HSA-2408508) involves 7 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AHCY CBS CTH GNMT HNMT LOC102724560 NNMT

Compounds Affecting Metabolism of ingested SeMet, Sec, MeSec into H2Se

#	Compound	Targets Hit	Studies
1	Aurintricarboxylic Acid	—	184
2	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
3	Crizotinib	—	298
4	Calcimycin	—	216
5	Dequalinium	—	136
6	Ticagrelor	—	299
7	tyrphostin ag 1478	—	4
8	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
9	Chlorhexidine	—	299
10	Cisplatin	—	300
11	darapladib [Supplementary Concept]	—	44
12	Dasatinib	—	299
13	Demeclocycline	—	297
14	Iodoacetamide	—	300
15	pictilisib	—	25
16	Vemurafenib	—	298
17	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
18	Thyroxine	—	994
19	Quercetin	—	300
20	2-Methoxyestradiol	—	300
21	Afatinib	—	297
22	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
23	Disulfiram	—	297
24	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
25	Estrone	—	300
26	Guanabenz	—	298
27	Methyldopa	—	297
28	Methylergonovine	—	193
29	Methysergide	—	300
30	piceatannol	—	300
31	propionylpromazine hydrochloride	—	2
32	scriptaid	—	53
33	Suramin	—	300
34	Thiorphan	—	300
35	Thyroxine	—	300
36	Triiodothyronine	—	300
37	tyrphostin 9	—	2
38	same	—	299
39	6-Aminonicotinamide	—	300
40	s adenosylmethionine	—	300
41	Adenosine	—	298
42	s adenosylhomocysteine	—	300

About the Metabolism of ingested SeMet, Sec, MeSec into H2Se Pathway

The Metabolism of ingested SeMet, Sec, MeSec into H2Se pathway is catalogued in Reactome (ID: R-HSA-2408508) and involves 7 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AHCY, CBS, CTH, GNMT, HNMT.