What compounds affect the SUMOylation of transcription factors pathway?

190 compounds in the BiohacksAI corpus have documented interactions with genes in the SUMOylation of transcription factors pathway (Reactome ID: R-HSA-3232118). These compounds target 4 genes within this pathway.

What genes are in the SUMOylation of transcription factors pathway?

The SUMOylation of transcription factors pathway involves 4 genes. Key genes include: MDM2, MITF, SUMO1, TP53.

SUMOylation of transcription factors

REACTOME PATHWAY

Reactome: R-HSA-32321184 genes190 compounds

The SUMOylation of transcription factors pathway (Reactome ID: R-HSA-3232118) involves 4 genes and is affected by 190 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

MDM2 MITF SUMO1 TP53

Compounds Affecting SUMOylation of transcription factors

#	Compound	Targets Hit	Studies
1	Hexachlorophene	—	300
2	Azacitidine	—	298
3	Azacitidine	—	300
4	Methylene Blue	—	200
5	Niclosamide	—	299
6	Ciclopirox	—	88
7	cycloheximide	—	300
8	Vorinostat	—	299
9	vinblastine sulfate	—	81
10	Digoxin	—	299
11	Nocodazole Nocodazole is	—	215
12	Oxyphenbutazone	—	300
13	Astemizole Antihistamine drug now withdrawn from	—	280
14	Demecolcine	—	246
15	tyrphostin 9	—	2
16	Ethidium	—	300
17	Bortezomib	—	300
18	Cladribine	—	297
19	Cytarabine	—	297
20	Melphalan	—	300
21	Methotrexate	—	289
22	Trifluridine	—	295
23	Camptothecin	—	300
24	Dinitrochlorobenzene	—	300
25	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
26	Spironolactone	—	298
27	Thioridazine	—	35
28	Topotecan	—	300
29	celastrol	—	300
30	Nisoldipine	—	297
31	rafoxanide	—	172
32	sp600125	—	117
33	Vincristine	—	299
34	Sertraline	—	1,000
35	Chlorhexidine	—	299
36	clofilium tosylate	—	4
37	Colchicine	—	300
38	Nitrofurantoin	—	297
39	Calcimycin	—	216
40	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
41	Anisomycin	—	247
42	colchine	—	2
43	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
44	Podophyllotoxin	—	14
45	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
46	Cefdinir	—	298
47	Oxytetracycline	—	300
48	Ethinyl Estradiol	—	300
49	Rotenone	—	300
50	Azathioprine	—	300

About the SUMOylation of transcription factors Pathway

The SUMOylation of transcription factors pathway is catalogued in Reactome (ID: R-HSA-3232118) and involves 4 genes. In the BiohacksAI corpus, 190 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MDM2, MITF, SUMO1, TP53.