What compounds affect the HSF1-dependent transactivation pathway?

66 compounds in the BiohacksAI corpus have documented interactions with genes in the HSF1-dependent transactivation pathway (Reactome ID: R-HSA-3371571). These compounds target 15 genes within this pathway.

What genes are in the HSF1-dependent transactivation pathway?

The HSF1-dependent transactivation pathway involves 15 genes. Key genes include: CAMK2B, CAMK2D, CREBBP, CRYAB, EP300, FKBP4, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B.

HSF1-dependent transactivation

REACTOME PATHWAY

Reactome: R-HSA-337157115 genes66 compounds

The HSF1-dependent transactivation pathway (Reactome ID: R-HSA-3371571) involves 15 genes and is affected by 66 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CAMK2B CAMK2D CREBBP CRYAB EP300 FKBP4 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA8 MLST8 MTOR PTGES3 RPTOR

Compounds Affecting HSF1-dependent transactivation

#	Compound	Targets Hit	Studies
1	Sirolimus	—	300
2	Everolimus	—	297
3	triolimus [Supplementary Concept]	—	33
4	gedunin	—	54
5	Quercetin	—	300
6	Idarubicin	—	299
7	torin 1	—	10
8	Ku 0063794 [Supplementary Concept]	—	7
9	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
10	Ergosterol	—	300
11	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
12	monorden	—	8
13	celastrol	—	300
14	Novobiocin	—	300
15	caffeic acid	—	300
16	Masoprocol	—	300
17	Tetracycline	—	300
18	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
19	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
20	ag490	—	14
21	Calcimycin	—	216
22	Disulfiram	—	297
23	Hexachlorophene	—	300
24	piceatannol	—	300
25	Nitroprusside	—	299
26	Wortmannin	—	300
27	egcg	—	300
28	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
29	sp600125	—	117
30	Adenosine Triphosphate	—	300
31	2-Chloroadenosine 2-Chloroadenosine.	—	300
32	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
33	Calcitriol	—	300
34	Ciclopirox	—	88
35	Clotrimazole	—	296
36	cycloheximide	—	300
37	deguelin [Supplementary Concept]	—	151
38	Indazoles	—	300
39	Miconazole	—	298
40	specioside	—	6
41	pictilisib	—	25
42	ly294002	—	11
43	Rotenone	—	300
44	Thapsigargin	—	300
45	alpelisib	—	227
46	amn082	—	29
47	Idazoxan	—	300
48	Niclosamide	—	299
49	tyrphostin 9	—	2
50	Ursolic Acid	—	300

About the HSF1-dependent transactivation Pathway

The HSF1-dependent transactivation pathway is catalogued in Reactome (ID: R-HSA-3371571) and involves 15 genes. In the BiohacksAI corpus, 66 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK2B, CAMK2D, CREBBP, CRYAB, EP300.