What compounds affect the Integrin signaling pathway?

241 compounds in the BiohacksAI corpus have documented interactions with genes in the Integrin signaling pathway (Reactome ID: R-HSA-354192). These compounds target 10 genes within this pathway.

What genes are in the Integrin signaling pathway?

The Integrin signaling pathway involves 10 genes. Key genes include: CSK, GRB2, ITGA2B, ITGB3, PDPK1, PTPN1, RAPGEF3, RAPGEF4, SRC, SYK.

Integrin signaling

REACTOME PATHWAY

Reactome: R-HSA-35419210 genes241 compounds

The Integrin signaling pathway (Reactome ID: R-HSA-354192) involves 10 genes and is affected by 241 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CSK GRB2 ITGA2B ITGB3 PDPK1 PTPN1 RAPGEF3 RAPGEF4 SRC SYK

Compounds Affecting Integrin signaling

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Daunorubicin	—	298
3	Hexachlorophene	—	300
4	Sorafenib	—	300
5	Quercetin	—	300
6	alsterpaullone	—	12
7	Idarubicin	—	299
8	kenpaullone	—	8
9	Evans Blue	—	300
10	Crizotinib	—	298
11	sp600125	—	117
12	Niclosamide	—	299
13	tyrphostin ag 1478	—	4
14	Axitinib	—	298
15	Nocodazole Nocodazole is	—	215
16	Methylene Blue	—	200
17	Ursolic Acid	—	300
18	Afatinib	—	297
19	celastrol	—	300
20	Clotrimazole	—	296
21	Ethynodiol Diacetate	—	300
22	monorden	—	8
23	Perphenazine	—	297
24	trequinsin hydrochloride	—	1
25	Night Vision Function of	—	56
26	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
27	Antimycin	—	300
28	Loratadine	—	296
29	Cyclic AMP	—	300
30	Cyclic AMP	—	300
31	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
32	Trapidil	—	292
33	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
34	Arachidonic Acid	—	245
35	Resveratrol	—	298
36	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
37	Aurintricarboxylic Acid	—	184
38	candesartan cilexetil [Supplementary Concept]	—	300
39	Dihydroxyphenylalanine	—	300
40	Masoprocol	—	300
41	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
42	Ouabain	—	300
43	Atorvastatin	—	1,000
44	Simvastatin	—	1,000
45	Methotrexate	—	289
46	Chlorhexidine	—	299
47	Clofarabine	—	298
48	Colchicine	—	300
49	cycloheximide	—	300
50	deguelin [Supplementary Concept]	—	151

About the Integrin signaling Pathway

The Integrin signaling pathway is catalogued in Reactome (ID: R-HSA-354192) and involves 10 genes. In the BiohacksAI corpus, 241 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSK, GRB2, ITGA2B, ITGB3, PDPK1.