What compounds target SYK?

BiohacksAI has identified 201 compounds that interact with SYK (spleen associated tyrosine kinase). Top compounds include: Dasatinib, Ouabain, Crizotinib, sp600125, Atorvastatin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SYK (spleen associated tyrosine)?

SYK is spleen associated tyrosine kinase. It is a molecular target for 201 compounds documented in PubMed bioassay data. NCBI Gene ID: 6850.

SYK

MOLECULAR TARGET

spleen associated tyrosine kinase

NCBI Gene: 6850201 compounds

SYK (spleen associated tyrosine kinase) is targeted by 201 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SYK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Dasatinib	2.30	9
2	Ouabain	1.95	6
3	Crizotinib	1.79	5
4	sp600125	1.79	5
5	Atorvastatin	1.61	4
6	Simvastatin	1.61	4
7	Methotrexate	1.61	4
8	Chlorhexidine	1.61	4
9	Clofarabine	1.61	4
10	Colchicine	1.61	4
11	cycloheximide	1.61	4
12	deguelin [Supplementary Concept]	1.61	4
13	Digoxin	1.61	4
14	Disulfiram	1.61	4
15	Emetine	1.61	4
16	Ezetimibe	1.61	4
17	Lovastatin	1.61	4
18	Medroxyprogesterone Acetate	1.61	4
19	Melphalan	1.61	4
20	Mometasone Furoate	1.61	4
21	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	1.61	4
22	Niclosamide	1.61	4
23	piceatannol	1.61	4
24	Podophyllotoxin	1.61	4
25	Thapsigargin	1.61	4
26	torin 1	1.61	4
27	trichostatic acid [Supplementary Concept] related to trichostatin	1.61	4
28	Trifluridine	1.61	4
29	tyrphostin ag 1478	1.61	4
30	fisetin	1.39	3
31	ag490	1.39	3
32	alpelisib	1.39	3
33	Axitinib	1.39	3
34	Azathioprine	1.39	3
35	Bortezomib	1.39	3
36	Maprotiline	1.39	3
37	Nocodazole Nocodazole is	1.39	3
38	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	1.39	3
39	Tripterygium	1.39	3
40	Vincristine	1.39	3
41	withaferin	1.39	3
42	Berberine	1.10	2
43	cbd	1.10	2
44	Doxycycline	1.10	2
45	Methylene Blue	1.10	2
46	Minocycline	1.10	2
47	Sertraline	1.10	2
48	Spermidine	1.10	2
49	Ursolic Acid	1.10	2
50	2-Methoxyestradiol	1.10	2

Showing top 50 of 201 compounds. Use the BiohacksAI search to explore all SYK modulators.

About SYK as a Drug Target

SYK (spleen associated tyrosine kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 201 compounds with documented SYK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SYK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.