Transcriptional regulation of white adipocyte differentiation

Q: What compounds affect the Transcriptional regulation of white adipocyte differentiation pathway?

191 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional regulation of white adipocyte differentiation pathway (Reactome ID: R-HSA-381340). These compounds target 24 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-38134024 genes191 compounds

The Transcriptional regulation of white adipocyte differentiation pathway (Reactome ID: R-HSA-381340) involves 24 genes and is affected by 191 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CARM1 CCNC CDK19 CDK4 CDK8 CREBBP EP300 FABP4 HDAC3 KLF5 NCOA1 NCOA3 NCOR1 NCOR2 NFKB1 NR2F2 PLIN1 PPARA PPARG RELA RXRA SLC2A4 SREBF1 SREBF2

Compounds Affecting Transcriptional regulation of white adipocyte differentiation

#	Compound	Targets Hit	Studies
1	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
2	Arachidonic Acid	—	245
3	Quercetin	—	300
4	cycloheximide	—	300
5	Trifluridine	—	295
6	alsterpaullone	—	12
7	Digoxin	—	299
8	Methylene Blue	—	200
9	urolithin b	—	49
10	Linoleic Acid	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Kaempferols	—	300
13	Resveratrol	—	298
14	Disulfiram	—	297
15	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
16	Oleic Acid	—	112
17	Rutin	—	300
18	Methotrexate	—	289
19	Hexachlorophene	—	300
20	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
21	Bortezomib	—	300
22	Podophyllotoxin	—	14
23	Ursolic Acid	—	300
24	Anisomycin	—	247
25	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
26	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
27	Tubercidin	—	300
28	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
29	Vorinostat	—	299
30	Sorafenib	—	300
31	Pioglitazone	—	297
32	Troglitazone	—	299
33	Thyroxine	—	994
34	Thyroxine	—	300
35	Genistein	—	300
36	Rotenone	—	300
37	alpha-Linolenic Acid	—	300
38	Bezafibrate	—	300
39	Mepentol [Supplementary Concept]	—	184
40	Ethidium	—	300
41	Fenofibrate	—	297
42	Niflumic Acid	—	300
43	Oxaprozin	—	181
44	Prostaglandin D2	—	300
45	Dehydroepiandrosterone Sulfate	—	300
46	Vitamin	—	295
47	Biotin	—	297
48	Dactinomycin	—	297
49	Dasatinib	—	299
50	Daunorubicin	—	298

About the Transcriptional regulation of white adipocyte differentiation Pathway

The Transcriptional regulation of white adipocyte differentiation pathway is catalogued in Reactome (ID: R-HSA-381340) and involves 24 genes. In the BiohacksAI corpus, 191 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CARM1, CCNC, CDK19, CDK4, CDK8.