What compounds affect the Co-stimulation by CD28 pathway?

55 compounds in the BiohacksAI corpus have documented interactions with genes in the Co-stimulation by CD28 pathway (Reactome ID: R-HSA-389356). These compounds target 22 genes within this pathway.

What genes are in the Co-stimulation by CD28 pathway?

The Co-stimulation by CD28 pathway involves 22 genes. Key genes include: AKT3, CDC42, FYN, GRB2, LCK, LYN, MAPKAP1, MLST8, MTOR, PDPK1.

Co-stimulation by CD28

REACTOME PATHWAY

Reactome: R-HSA-38935622 genes55 compounds

The Co-stimulation by CD28 pathway (Reactome ID: R-HSA-389356) involves 22 genes and is affected by 55 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 CDC42 FYN GRB2 LCK LYN MAPKAP1 MLST8 MTOR PDPK1 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PPP2CA PPP2R5A RICTOR SRC YES1

Compounds Affecting Co-stimulation by CD28

#	Compound	Targets Hit	Studies
1	Sirolimus	—	300
2	pictilisib	—	25
3	torin 1	—	10
4	ly294002	—	11
5	Wortmannin	—	300
6	Ku 0063794 [Supplementary Concept]	—	7
7	alpelisib	—	227
8	Dasatinib	—	299
9	Crizotinib	—	298
10	Sorafenib	—	300
11	tyrphostin ag 1478	—	4
12	kenpaullone	—	8
13	Quercetin	—	300
14	alsterpaullone	—	12
15	sp600125	—	117
16	Everolimus	—	297
17	Niclosamide	—	299
18	egcg	—	300
19	Axitinib	—	298
20	Resveratrol	—	298
21	Afatinib	—	297
22	Acetic Acid Product of	—	300
23	Okadaic Acid	—	300
24	Rotenone	—	300
25	Thapsigargin	—	300
26	amn082	—	29
27	Calcimycin	—	216
28	Idarubicin	—	299
29	Idazoxan	—	300
30	triolimus [Supplementary Concept]	—	33
31	tyrphostin 9	—	2
32	Ursolic Acid	—	300
33	Camptothecin	—	300
34	Dequalinium	—	136
35	Disulfiram	—	297
36	Emetine	—	298
37	Epinephrine	—	299
38	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
39	Maprotiline	—	299
40	Perphenazine	—	297
41	Kaempferols	—	300
42	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
43	Cladribine	—	297
44	Pioglitazone	—	297
45	Vemurafenib	—	298
46	Adenosine Monophosphate Adenine nucleotide containing	—	300
47	monorden	—	8
48	piceatannol	—	300
49	Swainsonine	—	300
50	Rosmarinic Acid	—	300

About the Co-stimulation by CD28 Pathway

The Co-stimulation by CD28 pathway is catalogued in Reactome (ID: R-HSA-389356) and involves 22 genes. In the BiohacksAI corpus, 55 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, CDC42, FYN, GRB2, LCK.