What genes are in the Nitric oxide stimulates guanylate cyclase pathway?

The Nitric oxide stimulates guanylate cyclase pathway involves 15 genes. Key genes include: GUCY1A1, GUCY1A2, GUCY1B1, KCNMA1, KCNMB1, KCNMB2, KCNMB4, NOS1, NOS2, NOS3.

Nitric oxide stimulates guanylate cyclase

Q: What compounds affect the Nitric oxide stimulates guanylate cyclase pathway?

63 compounds in the BiohacksAI corpus have documented interactions with genes in the Nitric oxide stimulates guanylate cyclase pathway (Reactome ID: R-HSA-392154). These compounds target 15 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-39215415 genes63 compounds

The Nitric oxide stimulates guanylate cyclase pathway (Reactome ID: R-HSA-392154) involves 15 genes and is affected by 63 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GUCY1A1 GUCY1A2 GUCY1B1 KCNMA1 KCNMB1 KCNMB2 KCNMB4 NOS1 NOS2 NOS3 PDE10A PDE1A PDE1B PDE2A PDE5A

Compounds Affecting Nitric oxide stimulates guanylate cyclase

#	Compound	Targets Hit	Studies
1	Papaverine	—	299
2	pterostilbene	—	299
3	Carvedilol	—	296
4	Fluocinolone Acetonide	—	295
5	Latanoprost	—	299
6	Nisoldipine	—	297
7	Promethazine	—	121
8	Thioridazine	—	35
9	nafadotride	—	14
10	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
11	Nortriptyline	—	28
12	Perphenazine	—	297
13	Ritonavir	—	298
14	Budesonide	—	1,000
15	Resveratrol	—	298
16	Ethylestrenol	—	70
17	Ezetimibe	—	296
18	Thyroxine	—	994
19	Amoxapine	—	259
20	Thyroxine	—	300
21	Nitroarginine	—	300
22	Arginine	—	300
23	Arginine	—	300
24	NG-Nitroarginine Methyl Ester	—	238
25	Benzydamine	—	298
26	Glyburide	—	298
27	Irbesartan	—	298
28	Simvastatin	—	1,000
29	Oxcarbazepine	—	296
30	Ursodeoxycholic Acid	—	298
31	Lovastatin	—	300
32	Nicardipine	—	94
33	Guanethidine	—	300
34	vinpocetine	—	299
35	Oxaprozin	—	181
36	Calcitriol	—	300
37	Chlorpheniramine	—	157
38	Desoximetasone	—	86
39	Disulfiram	—	297
40	Etodolac	—	296
41	Levonorgestrel	—	292
42	Norgestrel	—	300
43	Amdinocillin	—	100
44	Aminolevulinic Acid	—	299
45	Artemether	—	299
46	Cetirizine	—	296
47	Ethinyl Estradiol	—	300
48	Pemoline	—	300
49	Tocainide	—	299
50	Norethindrone Acetate Acetate ester of norethindrone that is used as	—	300

About the Nitric oxide stimulates guanylate cyclase Pathway

The Nitric oxide stimulates guanylate cyclase pathway is catalogued in Reactome (ID: R-HSA-392154) and involves 15 genes. In the BiohacksAI corpus, 63 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GUCY1A1, GUCY1A2, GUCY1B1, KCNMA1, KCNMB1.