What compounds affect the Sema3A PAK dependent Axon repulsion pathway?

45 compounds in the BiohacksAI corpus have documented interactions with genes in the Sema3A PAK dependent Axon repulsion pathway (Reactome ID: R-HSA-399954). These compounds target 6 genes within this pathway.

What genes are in the Sema3A PAK dependent Axon repulsion pathway?

The Sema3A PAK dependent Axon repulsion pathway involves 6 genes. Key genes include: CFL1, FES, FYN, HSP90AA1, HSP90AB1, LIMK1.

Sema3A PAK dependent Axon repulsion

REACTOME PATHWAY

Reactome: R-HSA-3999546 genes45 compounds

The Sema3A PAK dependent Axon repulsion pathway (Reactome ID: R-HSA-399954) involves 6 genes and is affected by 45 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CFL1 FES FYN HSP90AA1 HSP90AB1 LIMK1

Compounds Affecting Sema3A PAK dependent Axon repulsion

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Crizotinib	—	298
3	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
4	triolimus [Supplementary Concept]	—	33
5	monorden	—	8
6	gedunin	—	54
7	celastrol	—	300
8	Novobiocin	—	300
9	caffeic acid	—	300
10	Masoprocol	—	300
11	Tetracycline	—	300
12	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Quercetin	—	300
15	ag490	—	14
16	Clotrimazole	—	296
17	Idarubicin	—	299
18	piceatannol	—	300
19	Nitroprusside	—	299
20	kenpaullone	—	8
21	Sorafenib	—	300
22	2-Chloroadenosine 2-Chloroadenosine.	—	300
23	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
24	Calcimycin	—	216
25	Calcitriol	—	300
26	Ciclopirox	—	88
27	cycloheximide	—	300
28	deguelin [Supplementary Concept]	—	151
29	Disulfiram	—	297
30	Hexachlorophene	—	300
31	Indazoles	—	300
32	Miconazole	—	298
33	specioside	—	6
34	Wortmannin	—	300
35	Rosmarinic Acid	—	300
36	Genistein	—	300
37	egcg	—	300
38	Acetic Acid Product of	—	300
39	tyrphostin ag 1478	—	4
40	Sertraline	—	1,000
41	Cinnarizine	—	299
42	Clofibrate	—	299
43	Fenofibrate	—	297
44	Rotenone	—	300
45	sp600125	—	117

About the Sema3A PAK dependent Axon repulsion Pathway

The Sema3A PAK dependent Axon repulsion pathway is catalogued in Reactome (ID: R-HSA-399954) and involves 6 genes. In the BiohacksAI corpus, 45 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CFL1, FES, FYN, HSP90AA1, HSP90AB1.